The association of genetic variants IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510 with multiple sclerosis onset and severity in patients from Serbia

被引：7

作者：

Stefanovic, Milan ^{[1
]}

Zivotic, Ivan ^{[1
]}

Stojkovic, Ljiljana ^{[1
]}

Dincic, Evica ^{[2
]}

Stankovic, Aleksandra ^{[1
]}

Zivkovic, Maja ^{[1
]}

机构：

[1] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Lab Radiobiol & Mol Genet, POB 522, Belgrade 11000, Serbia

[2] Mil Med Acad, Clin Neurol, Belgrade, Serbia

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 347卷

关键词：

Multiple sclerosis; Genetic variants; IL2RA; IFI30; IKZF3; Disease severity; LYSOSOMAL THIOL REDUCTASE; DISULFIDE BONDS; SUSCEPTIBILITY; RISK; METAANALYSIS; DISABILITY; POLYMORPHISMS; IL7RA; GILT; AGE;

D O I：

10.1016/j.jneuroim.2020.577346

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An algorithm Probabilistic Identification of Causal SNPs, identified 434 causal variants for multiple sclerosis (MS) including IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510. Analysis of individual and combined effects of these variants in the Serbian population identified that Il2RA rs2104286 G allele carriers had a lower risk for developing MS (gender adjusted OR = 0.63, p = .003). With regard to the IFI30 rs11554159 recessive genetic model, among HLA-DRB1*15:01 positive patients, the AA homozygote had a significantly higher MSSS compared to the G allele carriers (p = .003). This study confirms role of IL2RA rs2104286 in MS and suggest the role of IFI30 rs11554159 in disease severity, which needs validation.

引用

页数：6

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