Activity of CD101, a long-acting echinocandin, against clinical isolates of Candida auris

被引：85
作者：
Berkow, Elizabeth L. [1 ]
Lockhart, Shawn R. [1 ]
机构：
[1] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2018年 / 90卷 / 03期
关键词：
CD101; Candida auris; Echinocandin; ANTIFUNGAL; RESISTANCE;
D O I：
10.1016/j.diagmicrobio.2017.10.021
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
CD101 is a new echinocandin with a prolonged half-life. CD101 was tested by broth microdilution against 100 isolates of the emerging yeast Candida auris. It showed activity against most isolates, including some that were resistant to other echinocandins. Published by Elsevier Inc.
引用
收藏
页码：196 / 197
页数：2
相关论文
共 14 条
  • [1] Multidrug-resistant Candida auris: 'new kid on the block' in hospital-associated infections?
    Chowdhary, A.
    Voss, A.
    Meis, J. F.
    [J]. JOURNAL OF HOSPITAL INFECTION, 2016, 94 (03) : 209 - 212
  • [2] CLSI, 2008, M27A3 CLSI, V28
  • [3] Echinocandin antifungal drugs
    Denning, DW
    [J]. LANCET, 2003, 362 (9390) : 1142 - 1151
  • [4] Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses
    Lockhart, Shawn R.
    Etienne, Kizee A.
    Vallabhaneni, Snigdha
    Farooqi, Joveria
    Chowdhary, Anuradha
    Govender, Nelesh P.
    Colombo, Arnaldo Lopes
    Calvo, Belinda
    Cuomo, Christina A.
    Desjardins, Christopher A.
    Berkow, Elizabeth L.
    Castanheira, Mariana
    Magobo, Rindidzani E.
    Jabeen, Kauser
    Asghar, Rana J.
    Meis, Jacques F.
    Jackson, Brendan
    Chiller, Tom
    Litvintseva, Anastasia P.
    [J]. CLINICAL INFECTIOUS DISEASES, 2017, 64 (02) : 134 - 140
  • [5] Ong V, 2017, ANTIMICROB AGENTS CH, V61, DOI [10.1128/aac.01626-16, 10.1128/AAC.01626-16]
  • [6] Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin
    Ong, Voon
    Hough, Grayson
    Schlosser, Michael
    Bartizal, Ken
    Balkovec, James M.
    James, Kenneth D.
    Krishnan, B. Radha
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (11) : 6872 - 6879
  • [7] Mechanisms of echinocandin antifungal drug resistance
    Perlin, David S.
    [J]. ANTIMICROBIAL THERAPEUTICS REVIEWS, 2015, 1354 : 1 - 11
  • [8] CD101, a long-acting echinocandin, and comparator antifungal agents tested against a global collection of invasive fungal isolates in the SENTRY 2015 Antifungal Surveillance Program
    Pfaller, Michael A.
    Messer, Shawn A.
    Rhomberg, Paul R.
    Castanheira, Mariana
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2017, 50 (03) : 352 - 358
  • [9] Pfaller MA, 2017, ANTIMICROB AGENTS CH, V61, DOI [10.1128/AAC.02045-16, 10.1128/aac.02045-16]
  • [10] Role of FKS Mutations in Candida glabrata: MIC Values, Echinocandin Resistance, and Multidrug Resistance
    Pham, Cau D.
    Iqbal, Naureen
    Bolden, Carol B.
    Kuykendall, Randall J.
    Harrison, Lee H.
    Farley, Monica M.
    Schaffner, William
    Beldavs, Zintars G.
    Chiller, Tom M.
    Park, Benjamin J.
    Cleveland, Angela A.
    Lockhart, Shawn R.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (08) : 4690 - 4696
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