A Prospective, Noninterventional Study of the Treatment of the Aging Hand with Juvederm Ultra® 3 and Juvederm® Hydrate

Hand rejuvenation aims to restore volume and produce smooth, elastic skin. A combined treatment has been proposed: Juv,derm Ultra(A (R)) 3 for filling and smoothing the skin and Juv,derm(A (R)) Hydrate to rehydrate and restore skin quality. Twenty physicians enrolled 99 subjects (i.e., 198 hands). At the first visit, hands were injected with Juv,derm Ultra(A (R)) 3. At the second visit (day 15) hands were treated with Juv,derm(A (R)) Hydrate. A final assessment was made at day 30. Ninety-eight percent of subjects were female (mean age = 60.3 years). Mean volumes injected were 1.02 ml Juv,derm Ultra(A (R)) 3 per hand at day 0 and 0.91 ml Juv,derm(A (R)) Hydrate per hand at day 15. Mean grading on the Hand Aging Scale was 3.18 preinjection, which decreased to 1.73 on study completion (p < 0.0001). Injections were rated as "very easy/easy" in 99.4 and 98.9 % of cases for Juv,derm Ultra(A (R)) 3 and Juv,derm(A (R)) Hydrate, respectively. Most physicians found both products "very easy/easy" to massage. Physician evaluation based on the Global Aesthetic Improvement Scale (GAIS) showed that the proportion of "very much/much improved" was significantly higher at days 15 and 30 compared to baseline (63.7 and 70.3 vs. 41.8 %). Patient GAIS scores showed that the proportion of "much improved" was significantly higher at day 30 than at day 15 (53.1 vs. 43.9 %). Over 94 % of physicians and approximately 90 % of subjects would recommend treatment. The adverse event rate was 8.2 %, including edema, hematoma, redness, and pain. Combined Juv,derm Ultra(A (R)) 3 and Juv,derm(A (R)) Hydrate treatment is effective and safe for rejuvenating the aging hand. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors at www.springer.com/00266.