Nucleic acid duplexes with metal-mediated base pairs and their structures

被引:84
作者
Mueller, Jens [1 ]
机构
[1] Westfalische Wilhelms Univ Munster, Inst Anorgan & Analyt Chem, Corrensstr 28-30, D-48149 Munster, Germany
关键词
Bioinorganic chemistry; Nucleic acids; Metal-mediated base pair; Structure; HG-II-T; STABILIZED RARE TAUTOMERS; DOUBLE-STRANDED POLYNUCLEOTIDES; CRYSTAL-STRUCTURE; DNA-DUPLEX; ARTIFICIAL NUCLEOBASE; DEOXYRIBONUCLEIC-ACID; DOUBLE-HELIX; REVERSIBLE-REACTION; MOLECULAR-STRUCTURE;
D O I
10.1016/j.ccr.2019.05.007
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Metal-mediated base pairs represent a topical area of research at the border of bioinorganic chemistry, supramolecular coordination chemistry and DNA nanotechnology. In a metal-mediated base pair, the hydrogen bonds of a canonical base pair are formally replaced by coordinate bonds to one or more metal ions located in the interior of the duplex. These base pairs can be created by using natural pyrimidine or purine nucleosides but may also involve artificial nucleosides. The review gives a survey of experimental nucleic acid structures containing one or more metal-mediated base pairs, including X-ray crystal structures as well as NMR solution structures. Starting with a selection of small-molecule structures involving model nucleobases, the overview is extended to nucleic acids structures with T-Hg(II)-T and C-Ag(I)-C base pairs formed from canonical pyrimidine bases, other metal-mediated base pairs involving natural nucleobases, and fully artificial metal-mediated base pairs. A comparison of the structures obtained under different experimental conditions allows to draw significant conclusions with respect to the conformational flexibility of metal-modified nucleic acids. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码:37 / 47
页数:11
相关论文
共 145 条
  • [21] Second generation silver(I)-mediated imidazole base pairs
    Hensel, Susanne
    Megger, Nicole
    Schweizer, Kristina
    Mueller, Jens
    [J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2014, 10 : 2139 - 2144
  • [22] SOLUTION STRUCTURE OF A CISPLATIN-INDUCED DNA INTERSTRAND CROSS-LINK
    HUANG, HF
    ZHU, LM
    REID, BR
    DROBNY, GP
    HOPKINS, PB
    [J]. SCIENCE, 1995, 270 (5243) : 1842 - 1845
  • [23] Atomic Structure of a Fluorescent Ag8 Cluster Templated by a Multistranded DNA Scaffold
    Huard, Dustin J. E.
    Demissie, Aida
    Kim, Dahye
    Lewis, David
    Dickson, Robert M.
    Petty, Jeffrey T.
    Lieberman, Raquel L.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 141 (29) : 11465 - 11470
  • [24] SITES AND THERMODYNAMIC QUANTITIES ASSOCIATED WITH PROTON AND METAL ION INTERACTION WITH RIBONUCLEIC ACID, DEOXYRIBONUCLEIC ACID, AND THEIR CONSTITUENT BASES, NUCLEOSIDES, AND NUCLEOTIDES
    IZATT, RM
    CHRISTENSEN, JJ
    RYTTING, JH
    [J]. CHEMICAL REVIEWS, 1971, 71 (05) : 439 - +
  • [25] Robust silver-mediated imidazolo-dC base pairs in metal DNA: dinuclear silver bridges with exceptional stability in double helices with parallel and antiparallel strand orientation
    Jana, Sunit Kumar
    Guo, Xiurong
    Mei, Hui
    Seela, Frank
    [J]. CHEMICAL COMMUNICATIONS, 2015, 51 (97) : 17301 - 17304
  • [26] A stable zinc(II)-mediated base pair in a parallel-stranded DNA duplex
    Jash, Biswarup
    Mueller, Jens
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2018, 186 : 301 - 306
  • [27] Concomitant Site-Specific Incorporation of Silver(I) and Mercury(II) Ions into a DNA Duplex
    Jash, Biswarup
    Mueller, Jens
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2018, 24 (42) : 10636 - 10640
  • [28] Stable Copper(I)-Mediated Base Pairing in DNA
    Jash, Biswarup
    Mueller, Jens
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (30) : 9524 - 9527
  • [29] Application of a Metal-Mediated Base Pair to the Detection of Medicinally Relevant Single Nucleotide Polymorphisms
    Jash, Biswarup
    Mueller, Jens
    [J]. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2017, (33) : 3857 - 3861
  • [30] A metal-mediated base pair that discriminates between the canonical pyrimidine nucleobases
    Jash, Biswarup
    Scharf, Philipp
    Sandmann, Nikolas
    Guerra, Celia Fonseca
    Megger, Dominik A.
    Mueller, Jens
    [J]. CHEMICAL SCIENCE, 2017, 8 (02) : 1337 - 1343