Effectiveness and impact of rotavirus vaccines in the United States-2006-2012

被引：80

作者：

Rha, Brian ^{[1
,2
]}

Tate, Jacqueline E. ^{[1
]}

Payne, Daniel C. ^{[1
]}

Cortese, Margaret M. ^{[1
]}

Lopman, Benjamin A. ^{[1
]}

Curns, Aaron T. ^{[1
]}

Parashar, Umesh D. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA

[2] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA

来源：

EXPERT REVIEW OF VACCINES | 2014年 / 13卷 / 03期

关键词：

gastroenteritis; rotavirus; rotavirus disease; rotavirus vaccines; vaccines; CHILDREN LESS-THAN-5 YEARS; US CHILDREN; GASTROENTERITIS HOSPITALIZATIONS; STATES CHILDREN; INTUSSUSCEPTION RISK; PROVIDES PROTECTION; ADVISORY-COMMITTEE; OLDER CHILDREN; DIARRHEA; PENTAVALENT;

D O I：

10.1586/14760584.2014.877846

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Prior to the introduction of rotavirus vaccines in 2006, rotavirus was the leading cause of severe gastroenteritis among US children <5 years of age. In the first 7 years of vaccine use, both recommended rotavirus vaccines (RotaTeq [RV5] and Rotarix [RV1]) have been shown to be highly effective in preventing outcomes of severe disease in US children in a variety of settings. In addition, substantial decreases in severe diarrheal disease in US children, exceeding the level expected based on vaccine coverage, as well as the extension of benefits to older age groups ineligible for vaccination have demonstrated both the direct and indirect impacts of vaccination in the USA.

引用

收藏

页码：365 / 376

页数：12

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