Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities

被引：32
|
作者：
McGinley, John [1 ]
McCann, Malachy [1 ]
Ni, Kaijie [1 ]
Tallon, Theresa [1 ]
Kavanagh, Kevin [2 ]
Devereux, Michael [3 ]
Ma, Xiaomei [4 ]
McKee, Vickie [4 ]
机构：
[1] Natl Univ Ireland Maynooth, Dept Chem, Maynooth, Kildare, Ireland
[2] Natl Univ Ireland Maynooth, Dept Biol, Maynooth, Kildare, Ireland
[3] Dublin Inst Technol, Inorgan Pharmaceut & Biomimet Res Ctr, Focas Res Inst, Dublin 8, Ireland
[4] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England
来源：
POLYHEDRON | 2013年 / 55卷
关键词：
Imidazoles; Schiff bases; Metal complexes; X-ray; Antimicrobial; Galleria mellonella; SILVER(I) COMPLEXES; METAL-COMPLEXES; IN-VITRO; ACID; 1,10-PHENANTHROLINE-5,6-DIONE; EFFICACY; DRUG;
D O I：
10.1016/j.poly.2013.03.023
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
1-(3-Aminopropyl)imidazole (Apim) reacts with salicylaldehyde and a selection of imidazole aldehydes and the resulting Schiff base ligands readily coordinate to Zn(II), Cu(II) and Ag(I) centres. X-ray crystal structures were obtained for two of the free ligands and also the Ag(I) complex of the Apim-salicylaldehyde ligand. Encouragingly, all of free ligands and most of their metal complexes are relatively non-toxic, in vivo, towards Galleria mellonella. Although the free ligands and the Cu(II) and Zn(II) complexes are inactive, in vitro, against a selection of microbial pathogens, most of the Ag(I) complexes exhibit moderate anti-bacterial activity and good anti-fungal activity. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：169 / 178
页数：10
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