Immunoglobulin M Concentration in Waldenstrom Macroglobulinemia: Correlation With Bone Marrow B Cells and Plasma Cells

被引：10

作者：

de Tute, Ruth M. ^{[1
]}

Rawstron, Andy C. ^{[1
]}

Owen, Roger G. ^{[1
]}

机构：

[1] Leeds Teaching Hosp NHS Trust, HMDS Lab, Leeds, W Yorkshire, England

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2013年 / 13卷 / 02期

关键词：

Immunoglobulin M; Plasma cell; Waldenstrom macroglobulinemia; FLOW-CYTOMETRY; MYELOMA; HETEROGENEITY; EXPRESSION; LYMPHOMA; THERAPY; WM;

D O I：

10.1016/j.clml.2013.02.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Serum immunoglobulin (Ig) M levels vary considerably among patients with Waldenstrom macroglobulinemia, and previous studies have failed to demonstrate a correlation with overall bone marrow disease burden. In this study, bone marrow B cells and plasma cells were enumerated by flow cytometry and correlated with serum IgM concentrations. Monotypic B cells comprised a median of 6% of bone marrow leukocytes but did not correlate with IgM levels (r = 0.071, P = .5). Plasma cells, although typically present in lower numbers (median, 0.52%) did show a correlation with IgM (r = 0.452, P = .01). IgM levels in Waldenstrom macroglobulinemia, at least in part, correlate with the degree of plasma cell differentiation seen within the tumor.

引用

页码：211 / 213

页数：3

共 20 条

[1] Residual Monotypic Plasma Cells in Patients With Waldenstrom Macroglobulinemia After Therapy [J].

Barakat, Fareed H. ;

Medeiros, L. Jeffrey ;

Wei, Eric X. ;

Konoplev, Sergej ;

Lin, Pei ;

Jorgensen, Jeffrey L. .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2011, 135 (03) :365-373

[2]

BARTL R, 1983, SCAND J HAEMATOL, V31, P359

[3] Phenotypic evolution of Waldenstrom's macroglobulinemia to extramedullary plasmacytoma [J].

Bashir, Qaiser ;

Lee, Choon-Kee ;

Stuart, Rodney W. ;

Smith, Maxwell L. ;

Ryder, John ;

Gonzalez, Ricardo .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (14) :2408-2410

[4] IgM myeloma:: a rare entity characterized by a CD20-CD56-CD117- immunophenotype and the t(11;14) [J].

Feyler, Sylvia ;

O'Connor, Sheila J. M. ;

Rawstron, Andy C. ;

Subash, Chezhian ;

Ross, Fiona M. ;

Pratt, Guy ;

Drayson, Mark T. ;

Ashcroft, John ;

Cook, Gordon ;

Owen, Roger G. .

BRITISH JOURNAL OF HAEMATOLOGY, 2008, 140 (05) :547-551

[5] CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma [J].

Hsi, Eric D. ;

Steinle, Roxanne ;

Balasa, Balaji ;

Szmania, Susann ;

Draksharapu, Aparna ;

Shum, Benny P. ;

Huseni, Mahrukh ;

Powers, David ;

Nanisetti, Amulya ;

Zhang, Yin ;

Rice, Audie G. ;

van Abbema, Anne ;

Wong, Melanie ;

Liu, Gao ;

Zhan, Fenghuang ;

Dillon, Myles ;

Chen, Shihao ;

Rhodes, Susan ;

Fuh, Franklin ;

Tsurushita, Naoya ;

Kumar, Shankar ;

Vexler, Vladimir ;

Shaughnessy, John D., Jr. ;

Barlogie, Bart ;

van Rhee, Frits ;

Hussein, Mohamad ;

Afar, Daniel E. H. ;

Williams, Marna B. .

CLINICAL CANCER RESEARCH, 2008, 14 (09) :2775-2784

[6] CD138 Expression Helps Distinguishing Waldenstrom's Macroglobulinemia (WM) From Splenic Marginal Zone Lymphoma (SMZL) [J].

Kyrtsonis, Marie-Christine ;

Levidou, Georgia ;

Korkolopoulou, Penelope ;

Koulieris, Efstathios ;

Bartzi, Vassiliki ;

Maltezas, Dimitrios ;

Pangalis, Gerassimos A. ;

Kalpadakis, Christina ;

Dimou, Maria ;

Georgiou, George ;

Vassilakopoulos, Theodoros P. ;

Angelopoulou, Maria K. ;

Salpeas, Vassilis ;

Tsaftaridis, Panagiotis ;

Patsouris, Efstratios ;

Panayiotidis, Panayiotis ;

Tzenou, Tatiana K. .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2011, 11 (01) :99-102

[7]

Morel P, 2012, EXPERT REV HEMATOL, V5, P187, DOI [10.1586/EHM.11.82, 10.1586/ehm.11.82]

[8] International prognostic scoring system for Waldenstrom macroglobulinemia [J].

Morel, Pierre ;

Duhamel, Alain ;

Gobbi, Paolo ;

Dimopoulos, Meletios A. ;

Dhodapkar, Madhav V. ;

McCoy, Jason ;

Crowley, John ;

Ocio, Enrique M. ;

Garcia-Sanz, Ramon ;

Treon, Steven P. ;

Leblond, Veronique ;

Kyle, Robert A. ;

Barlogie, Bart ;

Merlini, Giampaolo .

BLOOD, 2009, 113 (18) :4163-4170

[9] Novel immunophenotypic features of marrow lymphoplasmacytic lymphoma and correlation with Waldenstrom's macroglobulinemia [J].

Morice, William G. ;

Chen, Dong ;

Kurtin, Paul J. ;

Hanson, Curtis A. ;

McPhail, Ellen D. .

MODERN PATHOLOGY, 2009, 22 (06) :807-816

[10] Heterogeneity of Histological Transformation Events in Waldenstrom's Macroglobulinemia (WM) and Related Disorders [J].

Owen, R. G. ;

Bynoe, A. G. ;

Varghese, A. ;

de Tute, R. M. ;

Rawstron, A. C. .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2011, 11 (01) :176-179

← 1 2 →