Aggregation-Induced-Emissive Molecule Incorporated into Polymeric Nanoparticulate as FRET Donor for Observing Doxorubicin Delivery

被引：42

作者：

Han, Xiongqi ^{[1
]}

Liu, De-E ^{[1
]}

Wang, Tieyan ^{[1
]}

Lu, Hongguang ^{[1
]}

Ma, Jianbiao ^{[1
]}

Chen, Qixian ^{[2
]}

Gao, Hui ^{[1
]}

机构：

[1] Tianjin Univ Technol, Tianjin Key Lab Organ Solar Cells & Photochem Con, Sch Chem & Chem Engn, Tianjin 300384, Peoples R China

[2] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 42期

基金：

中国国家自然科学基金;

关键词：

aggregation-induced-emission; tetraphenylethene (TPE); poly(glycerol methacrylate) (PGMA); FRET; two-photon excitation; tumor target; NUCLEOCYTOPLASMIC TRANSPORT; DRUG-DELIVERY; POLY(GLYCEROL METHACRYLATE)S; MICELLES; CANCER; RELEASE; PHARMACOKINETICS; THERAPY; PRODRUG; PROBE;

D O I：

10.1021/acsami.5b08202

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Tetraphenylethene (TPE) derivatives characterized with distinct aggregation-induced-emission, attempted to aggregate with doxorubicin (Dox) to formulate the interior compartment of polymeric nanoparticulate, served as fluorescence resonance energy transfer (FRET) donor to promote emission of acceptor Dox. Accordingly, this FRET formulation allowed identification of Dox in complexed form by detecting FRET. Important insight into the Dox releasing can be subsequently explored by extracting complexed Dox (FRET) from the overall Dox via direct single-photon excitation of Dox. Of note, functional catiomers were used to complex with FRET partners for a template formulation, which was verified to induce pH-responsive release in the targeted subcellular compartment. Hence, this well-defined multifunctional system entitles in situ observation of the drug releasing profile and insight on drug delivery journey from the tip of injection vein to the subcellular organelle of the targeted cells.

引用

页码：23760 / 23766

页数：7

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