Inexpensive, universal serial bus-powered and fully portable lab-on-a-chip-based capillary electrophoresis instrument

被引：19

作者：

Kaigala, G. V. ^{[1
]}

Behnam, M. ^{[1
]}

Bliss, C. ^{[1
]}

Khorasani, M. ^{[1
]}

Ho, S. ^{[1
]}

McMullin, J. N. ^{[1
]}

Elliott, D. G. ^{[1
]}

Backhouse, C. J. ^{[1
]}

机构：

[1] Univ Alberta, Dept Elect & Comp Engn, Edmonton, AB T6G 2V4, Canada

来源：

IET NANOBIOTECHNOLOGY | 2009年 / 3卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

MICROCHIP; SEPARATIONS; MICROSYSTEM; PLATFORM; DISEASE; RISK; GENE; PCR;

D O I：

10.1049/iet-nbt:20080005

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Capillary electrophoresis is a cornerstone of lab-on-a-chip (LOC) implementations for medical diagnostics. However, the infrastructure needed to operate electrophoretic LOC implementations tends to be large and expensive, hindering the development of portable or low-cost systems. A custom-designed and highly integrated microelectronic chip for high-voltage generation switching and interfacing is recently developed. Here, the authors integrate the microelectronic chip with a microfluidic chip, a solid-state laser, filter, lens and several dollars worth of electronic components to form an inexpensive and portable platform, which is the size of a mobile telephone. This compact system has such reduced power requirements that the complete platform can be operated using a universal serial bus link to a computer. It is believed that this system represents a significant advancement in practical LOC implementations for point-of-care medical diagnostics.

引用

页码：1 / 7

页数：7

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