Neuroprotective effects of electrical stimulation of the anterior nucleus of the thalamus for hippocampus neurons in intractable epilepsy

被引：7

作者：

Chen, Ning ^{[1
]}

Yan, Na ^{[2
]}

Liu, Chong ^{[3
]}

Ge, Yan ^{[3
]}

Zhang, Jian-Guo ^{[1
]}

Meng, Fan-Gang ^{[3
]}

机构：

[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China

[2] Capital Med Univ, Sch Publ Hlth & Family Med, Beijing 100050, Peoples R China

[3] Capital Med Univ, Beijing Neurosurg Inst, Beijing 100050, Peoples R China

来源：

MEDICAL HYPOTHESES | 2013年 / 80卷 / 05期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

MILD COGNITIVE IMPAIRMENT; PENTYLENETETRAZOLE-KINDLED RATS; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; AMINO-ACIDS; BRAIN; CORTEX; MRI; CIRCUIT; TAURINE;

D O I：

10.1016/j.mehy.2013.02.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Epilepsy and Parkinson's disease (PD) are common neurological disorders. Both epilepsy and PD are potentially progressive disabling diseases that can be treated with the established therapy of deep brain stimulation (DBS). The difference in therapy is target selection and stimulation parameter modulation. The anterior nucleus of the thalamus (ANT) is chosen for intractable epilepsy and the subthalamic nucleus (STN) is chosen for PD. Long-term stable symptom control of STN DBS can be seen in PD patients while the positive effect of ANT-DBS can be observed in epilepsy patients. Experimental data and clinical evidence have been reported that indicate the neuroprotective property of STN DBS could be found in PD patients. Therefore, we hypothesize that the neuroprotective benefits of ANT DBS may be present in epilepsy patients. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：517 / 519

页数：3

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