Lipids on the move: Simulations of membrane pores, domains, stalks and curves

被引:363
作者
Marrink, Siewert J. [1 ,2 ]
de Vries, Alex H. [1 ,2 ]
Tieleman, D. Peter [3 ]
机构
[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, NL-9747 AG Groningen, Netherlands
[2] Univ Groningen, Zernike Inst Adv Mat, NL-9747 AG Groningen, Netherlands
[3] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2009年 / 1788卷 / 01期
基金
加拿大健康研究院;
关键词
Computer modeling; Molecular dynamics; Biological membrane; Non-lamellar phase; Self-assembly; Phase transformation; Membrane pore; Vesicle; Lipid flip-flop; MOLECULAR-DYNAMICS SIMULATIONS; DISSIPATIVE PARTICLE DYNAMICS; COARSE-GRAINED MODEL; COMPUTER-SIMULATIONS; PHASE-BEHAVIOR; VESICLE FUSION; ION-TRANSPORT; INTERMONOLAYER FRICTION; ANTIMICROBIAL PEPTIDES; MESOSCOPIC SIMULATIONS;
D O I
10.1016/j.bbamem.2008.10.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this review we describe the state-of-the-art of computer simulation studies of lipid membranes. We focus on collective lipid-lipid and lipid-protein interactions that trigger deformations of the natural lamellar membrane state, showing that many important biological processes including self-aggregation of membrane components into domains, the formation of non-lamellar phases, and membrane poration and curving, are now amenable to detailed simulation studies. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:149 / 168
页数:20
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