Lipids on the move: Simulations of membrane pores, domains, stalks and curves

被引：363
作者：
Marrink, Siewert J. [1 ,2 ]
de Vries, Alex H. [1 ,2 ]
Tieleman, D. Peter [3 ]
机构：
[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, NL-9747 AG Groningen, Netherlands
[2] Univ Groningen, Zernike Inst Adv Mat, NL-9747 AG Groningen, Netherlands
[3] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2009年 / 1788卷 / 01期
基金：
加拿大健康研究院;
关键词：
Computer modeling; Molecular dynamics; Biological membrane; Non-lamellar phase; Self-assembly; Phase transformation; Membrane pore; Vesicle; Lipid flip-flop; MOLECULAR-DYNAMICS SIMULATIONS; DISSIPATIVE PARTICLE DYNAMICS; COARSE-GRAINED MODEL; COMPUTER-SIMULATIONS; PHASE-BEHAVIOR; VESICLE FUSION; ION-TRANSPORT; INTERMONOLAYER FRICTION; ANTIMICROBIAL PEPTIDES; MESOSCOPIC SIMULATIONS;
D O I：
10.1016/j.bbamem.2008.10.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review we describe the state-of-the-art of computer simulation studies of lipid membranes. We focus on collective lipid-lipid and lipid-protein interactions that trigger deformations of the natural lamellar membrane state, showing that many important biological processes including self-aggregation of membrane components into domains, the formation of non-lamellar phases, and membrane poration and curving, are now amenable to detailed simulation studies. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：149 / 168
页数：20
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  • [11] Direct observation of Bin/amphiphysin/Rvs (BAR) domain-induced membrane curvature by means of molecular dynamics simulations
    Blood, Philip D.
    Voth, Gregory A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (41) : 15068 - 15072
  • [12] Kinetics, statistics, and energetics of lipid membrane electroporation studied by molecular dynamics simulations
    Boeckmann, Rainer A.
    de Groot, Bert L.
    Kakorin, Sergej
    Neumann, Eberhard
    Grubmueller, Helmut
    [J]. BIOPHYSICAL JOURNAL, 2008, 95 (04) : 1837 - 1850
  • [13] Bilayer deformation by the Kv channel voltage sensor domain revealed by self-assembly simulations
    Bond, Peter J.
    Sansom, Mark S. P.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (08) : 2631 - 2636
  • [14] Insertion and assembly of membrane proteins via simulation
    Bond, PJ
    Sansom, MSP
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (08) : 2697 - 2704
  • [15] Flexible lipid bilayers in implicit solvent
    Brannigan, G
    Philips, PF
    Brown, FLH
    [J]. PHYSICAL REVIEW E, 2005, 72 (01):
  • [16] A consistent model for thermal fluctuations and protein-induced deformations in lipid bilayers
    Brannigan, G
    Brown, FLH
    [J]. BIOPHYSICAL JOURNAL, 2006, 90 (05) : 1501 - 1520
  • [17] Elastic Modeling of biomembranes and lipid bilayers
    Brown, Frank L. H.
    [J]. ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 2008, 59 : 685 - 712
  • [18] Intrinsic curvature properties of photosynthetic proteins in chromatophores
    Chandler, Danielle E.
    Hsin, Jen
    Harrison, Christopher B.
    Gumbart, James
    Schulten, Klaus
    [J]. BIOPHYSICAL JOURNAL, 2008, 95 (06) : 2822 - 2836
  • [19] Structure of sphingomyelin bilayers: A simulation study
    Chiu, SW
    Vasudevan, S
    Jakobsson, E
    Mashl, RJ
    Scott, HL
    [J]. BIOPHYSICAL JOURNAL, 2003, 85 (06) : 3624 - 3635
  • [20] Emerging methods for multiscale simulation of biomolecular systems
    Chu, J. -W.
    Ayton, G. S.
    Izvekov, S.
    Voth, G. A.
    [J]. MOLECULAR PHYSICS, 2007, 105 (2-3) : 167 - 175
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