Lipids on the move: Simulations of membrane pores, domains, stalks and curves

被引：363
作者：
Marrink, Siewert J. [1 ,2 ]
de Vries, Alex H. [1 ,2 ]
Tieleman, D. Peter [3 ]
机构：
[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, NL-9747 AG Groningen, Netherlands
[2] Univ Groningen, Zernike Inst Adv Mat, NL-9747 AG Groningen, Netherlands
[3] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2009年 / 1788卷 / 01期
基金：
加拿大健康研究院;
关键词：
Computer modeling; Molecular dynamics; Biological membrane; Non-lamellar phase; Self-assembly; Phase transformation; Membrane pore; Vesicle; Lipid flip-flop; MOLECULAR-DYNAMICS SIMULATIONS; DISSIPATIVE PARTICLE DYNAMICS; COARSE-GRAINED MODEL; COMPUTER-SIMULATIONS; PHASE-BEHAVIOR; VESICLE FUSION; ION-TRANSPORT; INTERMONOLAYER FRICTION; ANTIMICROBIAL PEPTIDES; MESOSCOPIC SIMULATIONS;
D O I：
10.1016/j.bbamem.2008.10.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review we describe the state-of-the-art of computer simulation studies of lipid membranes. We focus on collective lipid-lipid and lipid-protein interactions that trigger deformations of the natural lamellar membrane state, showing that many important biological processes including self-aggregation of membrane components into domains, the formation of non-lamellar phases, and membrane poration and curving, are now amenable to detailed simulation studies. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：149 / 168
页数：20
相关论文
共 208 条
  • [1] Four-scale description of membrane sculpting by BAR domains
    Arkhipov, Anton
    Yin, Ying
    Schulten, Klaus
    [J]. BIOPHYSICAL JOURNAL, 2008, 95 (06) : 2806 - 2821
  • [2] Computer simulations of membrane proteins
    Ash, WL
    Zlomislic, MR
    Oloo, EO
    Tieleman, DP
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2004, 1666 (1-2): : 158 - 189
  • [3] Bridging microscopic and mesoscopic simulations of lipid bilayers
    Ayton, G
    Voth, GA
    [J]. BIOPHYSICAL JOURNAL, 2002, 83 (06) : 3357 - 3370
  • [4] Membrane remodeling from N-BAR domain interactions: Insights from multi-scale simulation
    Ayton, Gary S.
    Blood, Philip D.
    Voth, Gregory A.
    [J]. BIOPHYSICAL JOURNAL, 2007, 92 (10) : 3595 - 3602
  • [5] The molecular mechanism of lipid monolayer collapse
    Baoukina, Svetlana
    Monticelli, Luca
    Risselada, H. Jelger
    Marrink, Siewert J.
    Tieleman, D. Peter
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (31) : 10803 - 10808
  • [6] Phase and mixing behavior in two-component lipid bilayers: A molecular dynamics study in DLPC/DSPC mixtures
    Bennun, Sandra V.
    Longo, Margie
    Faller, Roland
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2007, 111 (32) : 9504 - 9512
  • [7] Berendsen H. J. C., 2007, Simulating the Physical World
  • [8] Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature
    Berger, O
    Edholm, O
    Jahnig, F
    [J]. BIOPHYSICAL JOURNAL, 1997, 72 (05) : 2002 - 2013
  • [9] Probing the molecular-scale lipid bilayer response to shear flow using nonequilibrium molecular dynamics
    Blood, PD
    Ayton, GS
    Voth, GA
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2005, 109 (39) : 18673 - 18679
  • [10] Factors influencing local membrane curvature induction by N-BAR domains as revealed by molecular dynamics simulations
    Blood, Philip D.
    Swenson, Richard D.
    Voth, Gregory A.
    [J]. BIOPHYSICAL JOURNAL, 2008, 95 (04) : 1866 - 1876
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