The engraftment of transplanted bone marrow-derived cells into the inner ear

被引：0

作者：

Orita, Yorihisa ^{[1
]}

Tsujigiwa, Hidetsugu ^{[2
,3
]}

Nishizaki, Kazunori ^{[4
]}

Teshima, Takanori ^{[5
]}

Yoshinobu, Junko ^{[4
]}

Orita, Saeko ^{[4
]}

Takeuchi, Ayako ^{[4
]}

Takeda, Yasushi ^{[4
]}

Nagatsuka, Hitoshi ^{[2
,3
]}

Nagai, Noriyuki ^{[2
,3
]}

机构：

[1] Okayama Saiseikai Gen Hosp, Dept Otolaryngol Head & Neck Surg, Okayama 7008511, Japan

[2] Okayama Univ, Grad Sch Med & Dent, Dept Oral Pathol, Okayama, Japan

[3] Okayama Univ, Grad Sch Med & Dent, Dept Med, Okayama, Japan

[4] Okayama Univ, Grad Sch Med & Dent, Dept Otolaryngol Head & Neck Surg, Okayama, Japan

[5] Okayama Univ, Grad Sch Med & Dent, Dept Blood Med, Okayama, Japan

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2009年 / 266卷 / 01期

关键词：

Bone marrow; Transplantation; Inner ear; Engraftment; GFP mice; HEMATOPOIETIC STEM-CELLS; HAIR-CELLS; SENSORY EPITHELIA; IN-VITRO; MICE; REGENERATION; OTOTOXICITY; GENTAMICIN; EXPRESSION; COCHLEA;

D O I：

10.1007/s00405-008-0725-6

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

To investigate whether bone marrow-derived cells (BMC) would migrate and engraft into the sensory epithelium of the inner ear, BMC of green fluorescence protein (GFP) mice were transplanted into lethally irradiated recipient mice. Then the recipient mice were treated with streptomycin and immunohistochemical staining was performed to evaluate the migration and engraftment of donor BMC into the sensory epithelium of the inner ear. Immunohistochemical staining for GFP was found initially in the vascular epithelium and oral mucosa but not in the sensory epithelium of the inner ear. In the case of mouse, BMC may not migrate and be engrafted into the sensory epithelium of the inner ear.

引用

页码：59 / 63

页数：5

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