SYNTHESIS AND CHARACTERIZATION OF SOME NEW 5-CHLORO-2-HYDROXY-N-PHENYLBENZAMIDE DERIVATIVES

There has been significant interest in the development of new compounds possessing an azometine group (NHN=CH-) due to their varied potential biological activities. With the purpose of obtaining novel compounds with a wide spectrum of pharmaceutical applications, the synthesis of 5-chloro-2-hydroxy-N-phenylbenzamide methyl esters, hydrazides and hydrazones was achieved. The synthesized compounds are crystalline substances whose purification required simple crystallization from absolute ethanol or dimethylformamide. The methyl esters were obtained in yields between 48-65%, while, for the hydrazides and hydrazones higher yields were obtained (84-96%). Useful tools, FTIR, H-1-NMR, C-13-NMR, MS, were used to identify and to characterize the synthetized compounds.