Prevalence of and Indications for Antipsychotic Use in Parkinson's Disease

被引：7

作者：

Bower, James H. ^{[1
]}

Grossardt, Brandon R. ^{[2
]}

Rocca, Walter A. ^{[1
,3
]}

Savica, Rodolfo ^{[1
,3
]}

机构：

[1] Mayo Clin, Coll Med, Dept Neurol, Rochester, MN 55905 USA

[2] Mayo Clin, Div Biomed Stat & Informat, Dept Hlth Sci Res, Coll Med, Rochester, MN 55905 USA

[3] Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Coll Med, Rochester, MN 55905 USA

来源：

MOVEMENT DISORDERS | 2018年 / 33卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Parkinson's disease; prevalence; antipsychotics; dementia; ROCHESTER EPIDEMIOLOGY PROJECT; MEDICAL-RECORDS-LINKAGE; POPULATION; PSYCHOSIS; PATTERNS; SYSTEM;

D O I：

10.1002/mds.27256

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The prevalence of patients with PD taking antipsychotics is unknown. Objective: To measure the prevalence of patients with PD taking antipsychotics. Methods: We used the medical records-linkage system of the Rochester Epidemiology Project to study the use of antipsychotic medication in all persons with Parkinson disease in Olmsted County, Minnesota on 1 January 2006. Results: There were 296 patients with PD in Olmsted County on 1 January 2006. The overall prevalence of antipsychotic use was 9.8% (29 of 296); 95.5% (28 of 29) of the patients had dementia when initiating antipsychotics. The most frequent indication (71.4%; 20 of 28) was psychosis or behavior threatening to the patient or others. Conclusions: The prevalence of antipsychotic use in patients with PD is lower than expected from previously reported cumulative incidences. Dementia is highly prevalent in those starting antipsychotics. Most of the patients on antipsychotics had a reasonable risk-benefit ratio for taking them. (c) 2017 International Parkinson and Movement Disorder Society

引用

页码：325 / 328

页数：4

共 16 条

[1] Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976-1990 [J].

Bower, JH ;

Maraganore, DM ;

McDonnell, SK ;

Rocca, WA .

NEUROLOGY, 1999, 52 (06) :1214-1220

[2]

*FDA, 2008, SAF LAB CHANG ANT DR

[3] The Changing Face of Parkinson's Disease-Associated Psychosis: A Cross-Sectional Study Based on the New NINDS-NIMH Criteria [J].

Fenelon, Gilles ;

Soulas, Thierry ;

Zenasni, Franck ;

de Langavant, Laurent Cleret .

MOVEMENT DISORDERS, 2010, 25 (06) :763-766

[4]

Forsaa EB, 2010, ARCH NEUROL-CHICAGO, V67, P996, DOI 10.1001/archneurol.2010.166

[5] Antipsychotic use in older adults with Parkinson's disease [J].

Marras, Connie ;

Kopp, Alexander ;

Qiu, Feng ;

Lang, Anthony E. ;

Sykora, Kathy ;

Shulman, Kenneth I. ;

Rochon, Paula A. .

MOVEMENT DISORDERS, 2007, 22 (03) :319-323

[6] Antipsychotics and Mortality in Parkinsonism [J].

Marras, Connie ;

Gruneir, Andrea ;

Wang, Xuesong ;

Fischer, Hadas ;

Gill, Sudeep S. ;

Herrmann, Nathan ;

Anderson, Geoffrey M. ;

Hyson, Christopher ;

Rochon, Paula A. .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2012, 20 (02) :149-158

[7] History of the Rochester Epidemiology Project: Half a Century of Medical Records Linkage in a US Population [J].

Rocca, Walter A. ;

Yawn, Barbara P. ;

St Sauver, Jennifer L. ;

Grossardt, Brandon R. ;

Melton, L. Joseph, III .

MAYO CLINIC PROCEEDINGS, 2012, 87 (12) :1202-1213

[8]

Savica R, 2017, MOV DISORD IN PRESS

[9] Incidence and Pathology of Synucleinopathies and Tauopathies Related to Parkinsonism [J].

Savica, Rodolfo ;

Grossardt, Brandon R. ;

Bower, James H. ;

Ahlskog, J. Eric ;

Rocca, Walter A. .

JAMA NEUROLOGY, 2013, 70 (07) :859-866

[10] Data Resource Profile: The Rochester Epidemiology Project (REP) medical records-linkage system [J].

St Sauver, Jennifer L. ;

Grossardt, Brandon R. ;

Yawn, Barbara P. ;

Melton, L. Joseph, III ;

Pankratz, Joshua J. ;

Brue, Scott M. ;

Rocca, Walter A. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2012, 41 (06) :1614-1624

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