Expression of A42, -Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer's Disease and Rate of Aging

被引：4

作者：

Zuev, V. A. ^{[1
]}

Dyatlova, A. S. ^{[1
,2
]}

Lin'kova, N. S. ^{[1
,2
]}

Kvetnaya, T. V. ^{[1
]}

机构：

[1] St Petersburg Res Ctr Inst Bioregulat & Gerontol, St Petersburg, Russia

[2] Peter Great St Petersburg Polytech Univ, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2019年 / 166卷 / 05期

关键词：

buccal epithelium; Alzheimer's disease; A42; protein; -protein; aging; BIOMARKERS; CELLS; SERUM;

D O I：

10.1007/s10517-019-04416-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The expression of A42, and -protein, and p16 and p53 proteins was analyzed in the buccal epithelium of elderly and senile patients with Alzheimer's disease. We revealed enhanced synthesis of Alzheimer's disease markers A42 (by 15-30 times) and -protein (by 5 times) in comparison with the corresponding values in people without neurodegenerative pathology of the same age groups. In addition, increased synthesis of proteins of cell aging and apoptosis p16 (by 6-10 times) and p53 (by 2-3 times) was observed in patients in comparison with age-matched persons without neuropathology. These data suggest that complex analysis of the expression of A42, -protein, p16, and p53 in the buccal epithelium is a promising method for in vivo diagnosis of Alzheimer's disease and assessment of the rate of aging during the development of this pathology.

引用

页码：676 / 679

页数：4

共 14 条

[1] Expression of Aβ42, τ-Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer’s Disease and Rate of Aging
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T. V. Kvetnaya
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