Hydroxyethylated graphene oxide as potential carriers for methotrexate delivery

被引：19
作者：
Du, Libo [1 ]
Suo, Siqingaowa [1 ]
Luo, Dan [2 ,3 ]
Jia, Hongying [1 ]
Sha, Yinlin [2 ,3 ]
Liu, Yang [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
[2] Peking Univ, Sch Basic Med Sci, Dept Biophys, Single Mol & Nanobiol Lab, Beijing 100191, Peoples R China
[3] Peking Univ, Biomed X Ctr, Beijing 100191, Peoples R China
来源：
JOURNAL OF NANOPARTICLE RESEARCH | 2013年 / 15卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Graphene; Methotrexate; Drug delivery; Cytotoxicity; Anticancer drugs; CONTROLLED-RELEASE; CARBON NANOTUBES; DOXORUBICIN; DRUGS; NANOCARRIER;
D O I：
10.1007/s11051-013-1708-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, we presented a simple approach to prepare hydroxyethylated graphene oxide (HE-GO) with high water solubility and physiological stability. The successful synthesis of HE-GO was confirmed by UV-Vis spectroscopy, Fourier transform infrared spectroscopy, and atomic force microscopy. The loading of anticancer drug methotrexate (MTX) onto this nanocarrier (MTX/HE-GO) was investigated. The results of in vitro drug release experiment showed that the rate of MTX release from MTX/HE-GO was pH dependent. Moreover, cell viability assay demonstrated that HE-GO loaded with MTX exhibits higher anticancer activity against human lung adenocarcinoma epithelial cell line than non-vehicle MTX.
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页数：7
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