RETRACTED: siVEGF-loaded nanoparticle uptake by tumor-associated vascular endothelial cells for hepatocellular carcinoma (Retracted article. See vol. 17, pg. 423, 2022)

被引：5

作者：

Xu, Bohui ^{[1
]}

Zhang, Yan ^{[1
]}

Yang, Han ^{[1
]}

Liu, Tingting ^{[1
]}

Lu, Youjia ^{[1
]}

Xu, Yan ^{[1
]}

Zhang, Qifeng ^{[1
]}

Li, Xingyu ^{[2
]}

Huang, Zhiqi ^{[2
]}

Zhang, Yuanyuan ^{[3
,4
,5
]}

Webster, Thomas J. ^{[6
]}

机构：

[1] Nantong Univ, Sch Pharm, Dept Pharmaceut, Nantong 226001, Peoples R China

[2] Nantong Univ, Dept Pathol, Med Sch, Nantong 226001, Peoples R China

[3] Nanjing Med Univ, Pharm Dept, Jiangsu Canc Hosp, Nanjing 21009, Peoples R China

[4] Nanjing Med Univ, Jiangsu Inst Canc Res, Nanjing 21009, Peoples R China

[5] Nanjing Med Univ, Affiliated Canc Hosp, Nanjing 21009, Peoples R China

[6] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA

来源：

NANOMEDICINE | 2020年 / 15卷 / 13期

关键词：

antiangiogenesis; antitumor growth; hepatocellular carcinoma; siVEGF; tumor-associated vascular endothelial cells; GROWTH-FACTOR; CO-DELIVERY; ANGIOGENESIS; EXPRESSION; STRATEGIES; INDUCTION; TARGET; SIRNA;

D O I：

10.2217/nnm-2020-0082

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: This study examined nanoparticle entry into tumor-associated vascular endothelial cells during transport to hepatocellular carcinoma cells and tumors. Materials & methods: siVEGF was loaded into CS-SS-9R/BSA-cRGD nanoparticles (CBc NPs). The intracellular uptake, gene silencing efficiency, antiproliferation and antiangiogenic effect of the NPs were performed on EA.hy926 cells. In vivo antitumor and antiangiogenic effects were investigated in Bel-7402 tumor-bearing nude mice. Results: siVEGF-loaded CBc NPs entered EA.hy926 cells and suppressed their proliferation and capillary formation. The NPs also inhibited tumor proliferation and angiogenesis in tumor-bearing mice, which attributed to the downregulation of VEGF mRNA expression in tumor tissue. Conclusion: The uptake of siVEGF-loaded CBc NPs by tumor-associated vascular endothelial cells made important contributions in controlling the progression of hepatocellular carcinoma.

引用

页码：1297 / 1314

页数：18

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