Synthesis and Antimicrobial Activity of New Substituted 5-(Pyridine-3-yl)-1,3,4-Thiadiazoles and Their Sugar Derivatives

被引：14
作者：
El-Sayed, Wael A. [1 ]
Metwally, Mohamed A. [2 ]
Nada, Doaa S. [3 ]
Mohamed, Asem A. [4 ]
Abdel-Rahman, Adel A. -H. [3 ]
机构：
[1] Natl Res Ctr, Dept Photochem, Cairo, Egypt
[2] Mansoura Univ, Fac Sci, Mansoura 35516, Egypt
[3] Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt
[4] Natl Res Ctr, Chem Nat & Microbial Prod Dept, Cairo, Egypt
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 50卷 / 02期
关键词：
C-FURYL GLYCOSIDES; MICROWAVE IRRADIATION; ANTIVIRAL EVALUATION; AGENTS; ANALOGS; 1,3,4-THIADIAZOLE; 1,2,4-TRIAZOLE; HETEROCYCLES; NUCLEOSIDES; INHIBITORS;
D O I：
10.1002/jhet.901
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New substituted 5-(pyridine-3-yl)-1,3,4-thiadiazoles, their sugar hydrazones and acyclic C-nucleoside analogs as well as the corresponding thioglycoside derivatives were synthesized. The synthesized compounds were tested for their antimicrobial activity against Escherichia coli, Bacillus subtilis, Staph aureus, Aspergillus niger, and Candida albicans The obtained results indicated that most of tested compounds exhibited moderate to high antimicrobial activity while few compounds were found to exhibit little or no activity against the tested microorganisms.
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收藏
页码：194 / 201
页数：8
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