Implementation of Nutritional Strategies Decreases Postnatal Growth Restriction in Preterm Infants

被引：53

作者：

Roggero, Paola ^{[1
]}

Gianni, Maria L. ^{[1
]}

Orsi, Anna ^{[1
]}

Amato, Orsola ^{[1
]}

Piemontese, Pasqua ^{[1
]}

Liotto, Nadia ^{[1
]}

Morlacchi, Laura ^{[1
]}

Taroni, Francesca ^{[1
]}

Garavaglia, Elisa ^{[1
]}

Bracco, Beatrice ^{[1
]}

Agosti, Massimo ^{[1
,2
]}

Mosca, Fabio ^{[1
]}

机构：

[1] Univ Milan, NICU, Dept Clin Sci & Comun Hlth, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[2] Del Ponte Hosp, Maternal & Child Hlth Dept, AO Circolo Fdn, Varese, Italy

来源：

PLOS ONE | 2012年 / 7卷 / 12期

关键词：

BIRTH-WEIGHT INFANTS; RANDOMIZED CONTROLLED-TRIAL; BODY-COMPOSITION; NEONATAL OUTCOMES; PROTEIN;

D O I：

10.1371/journal.pone.0051166

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Prevention of postnatal growth restriction of very preterm infants still represents a challenge for neonatologists. As standard feeding regimens have proven to be inadequate. Improved feeding strategies are needed to promote growth. Aim of the present study was to evaluate whether a set of nutritional strategies could limit the postnatal growth restriction of a cohort of preterm infants. Methodology/Principal Findings: We performed a prospective non randomized interventional cohort study. Growth and body composition were assessed in 102 very low birth weight infants after the introduction of a set of nutritional practice changes. 69 very low birth weight infants who had received nutrition according to the standard nutritional feeding strategy served as a historical control group. Weight was assessed daily, length and head circumference weekly. Body composition at term corrected age was assessed using an air displacement plethysmography system. The cumulative parenteral energy and protein intakes during the first 7 days of life were higher in the intervention group than in the historical group (530 +/- 81 vs 300 +/- 93 kcal/kg, p<0.001 and 21 +/- 2.9 vs 15 +/- 3.2 g/kg, p<0.01). During weaning from parenteral nutrition, the intervention group received higher parental/enteral energy and protein intakes than the historical control group (1380 +/- 58 vs 1090 +/- 70 kcal/kg; 52.6 +/- 7 vs 42.3 +/- 10 g/kg, p<0.01). Enteral energy (kcal/kg/d) and protein (g/kg/d) intakes in the intervention group were higher than in the historical group (130 +/- 11 vs 100 +/- 13; 3.5 +/- 0.5 vs 2.2 +/- 0.6, p<0.01). The negative changes in z score from birth to discharge for weight and head circumference were significantly lower in the intervention group as compared to the historical group. No difference in fat mass percentage between the intervention and the historical groups was found. Conclusions: The optimization and the individualization of nutritional intervention promote postnatal growth of preterm infants without any effect on percentage of fat mass.

引用

页数：6

共 21 条

[1] Enteral Nutrient Supply for Preterm Infants: Commentary From the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Committee on Nutrition [J].