Cancer cell detection based on the interaction between an anticancer drug and cell membrane components

被引：63
作者：
Chandra, Pranjal
Noh, Hui-Bog
Shim, Yoon-Bo [1 ]
机构：
[1] Pusan Natl Univ, Dept Chem, Pusan 609735, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 19期
关键词：
DAUNOMYCIN; AFFINITY; APTAMER;
D O I：
10.1039/c2cc38235k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Simple and general cancer cell detection methods are required in point-of-care diagnostics. Herein, the interaction between an anticancer drug, daunomycin, and cancer cell membrane components has been studied using an aptamer probe immobilized on a conducting polymer-gold nanoparticle composite film through electrochemical and fluorescence methods and applied to the quantitative detection of cancer cells. The developed method differentiates between cancerous and non-cancerous cells effectively.
引用
收藏
页码：1900 / 1902
页数：3
相关论文
共 20 条
  • [1] ABERCROMBIE M, 1962, CANCER RES, V22, P525
  • [2] Study of serum haptoglobin and its glycoforms in the diagnosis of hepatocellular carcinoma: A glycoproteomic approach
    Ang, Irene L.
    Poon, Terence C. W.
    Lai, Paul B. S.
    Chan, Anthony T. C.
    Ngai, Sai-Ming
    Hui, Alex Y.
    Johnson, Philip J.
    Sung, Joseph J. Y.
    [J]. JOURNAL OF PROTEOME RESEARCH, 2006, 5 (10) : 2691 - 2700
  • [3] Visualization of cytoskeletal elements by the atomic force microscope
    Berdyyeva, T
    Woodworth, CD
    Sokolov, I
    [J]. ULTRAMICROSCOPY, 2005, 102 (03) : 189 - 198
  • [4] Regulatory mechanisms in maintenance and modulation of transmembrane lipid asymmetry: Pathophysiological implications
    Bevers, EM
    Comfurius, P
    Zwaal, RFA
    [J]. LUPUS, 1996, 5 (05) : 480 - 487
  • [5] Detection of daunomycin using phosphatidylserine and aptamer co-immobilized on Au nanoparticles deposited conducting polymer
    Chandra, Pranjal
    Noh, Hui-Bog
    Won, Mi-Sook
    Shim, Yoon-Bo
    [J]. BIOSENSORS & BIOELECTRONICS, 2011, 26 (11) : 4442 - 4449
  • [6] Electrochemical detection of mismatched DNA using a MutS probe
    Cho, Minseon
    Lee, Sohyun
    Han, Se-Young
    Park, Jin-Young
    Rahman, Md Aminur
    Shim, Yoon-Bo
    Ban, Changill
    [J]. NUCLEIC ACIDS RESEARCH, 2006, 34 (10)
  • [7] Electropolymerized Self-Assembled Layer on Gold Nanoparticles: Detection of Inducible Nitric Oxide Synthase in Neuronal Cell Culture
    Choon, Wei
    Koh, Alvin
    Chandra, Pranjal
    Kim, Dong-Min
    Shim, Yoon-Bo
    [J]. ANALYTICAL CHEMISTRY, 2011, 83 (16) : 6177 - 6183
  • [8] Nanomechanical analysis of cells from cancer patients
    Cross, Sarah E.
    Jin, Yu-Sheng
    Rao, Jianyu
    Gimzewski, James K.
    [J]. NATURE NANOTECHNOLOGY, 2007, 2 (12) : 780 - 783
  • [9] ROLE OF MEMBRANE-LIPIDS IN THE INTERACTION OF DAUNOMYCIN WITH PLASMA-MEMBRANES FROM TUMOR-CELLS - IMPLICATIONS IN DRUG-RESISTANCE PHENOMENA
    ESCRIBA, PV
    FERRERMONTIEL, AV
    FERRAGUT, JA
    GONZALEZROS, JM
    [J]. BIOCHEMISTRY, 1990, 29 (31) : 7275 - 7282
  • [10] Multiplexed protein detection by proximity ligation for cancer biomarker validation
    Fredriksson, Simon
    Dixon, William
    Ji, Hanlee
    Koong, Albert C.
    Mindrinos, Michael
    Davis, Ronald W.
    [J]. NATURE METHODS, 2007, 4 (04) : 327 - 329
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