Cancer cell detection based on the interaction between an anticancer drug and cell membrane components

被引：63

作者：

Chandra, Pranjal

Noh, Hui-Bog

Shim, Yoon-Bo ^{[1
]}

机构：

[1] Pusan Natl Univ, Dept Chem, Pusan 609735, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 19期

关键词：

DAUNOMYCIN; AFFINITY; APTAMER;

D O I：

10.1039/c2cc38235k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simple and general cancer cell detection methods are required in point-of-care diagnostics. Herein, the interaction between an anticancer drug, daunomycin, and cancer cell membrane components has been studied using an aptamer probe immobilized on a conducting polymer-gold nanoparticle composite film through electrochemical and fluorescence methods and applied to the quantitative detection of cancer cells. The developed method differentiates between cancerous and non-cancerous cells effectively.

引用

收藏

页码：1900 / 1902

页数：3

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