Regulation of APC/C Activators in Mitosis and Meiosis

被引：252
作者：
Pesin, Jillian A.
Orr-Weaver, Terry L. [1 ]
机构：
[1] Whitehead Inst, Cambridge, MA 02142 USA
来源：
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2008年 / 24卷
关键词：
Cdc20; Cdh1; Emi1; spindle assembly checkpoint; meiosis-specific activators; Emi2;
D O I：
10.1146/annurev.cellbio.041408.115949
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase that triggers the degradation of multiple substrates during mitosis. Cdc20/Fizzy and Cdh1/Fizzy-related activate APC/C and confer substrate specificity through complex interactions with both the core APC/C and substrate proteins. The regulation of Cdc20 and Cdh1 is critical for proper APC/C activity and occurs in multiple ways: targeted protein degradation, phosphorylation, and direct binding of inhibitorv proteins. During the specialized divisions of meiosis, the activity of the APC/C must be modified to achieve proper chromosome segregation. Recent studies show that one way in which APC/C activity is modified is through the use of meiosis-specific APC/C activators. Furthermore, regulation of the APC/C (during meiosis is carried out by both mitotic regulators of the APC/C as well as meiosis-specific regulators. Here, we review the regulation of APC/C activators during mitosis and the role and regulation of the APC/C during female meiosis.
引用
收藏
页码：475 / 499
页数：25
相关论文
共 138 条
[1]   A novel Cdc20-related WD-repeat protein, Fzr1, is required for spore formation in Schizosaccharomyces pombe [J].
Asakawa, H ;
Kitamura, K ;
Shimoda, C .
MOLECULAR GENETICS AND GENOMICS, 2001, 265 (03) :424-435
[2]   BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice [J].
Baker, DJ ;
Jeganathan, KB ;
Cameron, JD ;
Thompson, M ;
Juneja, S ;
Kopecka, A ;
Kumar, R ;
Jenkins, RB ;
de Groen, PC ;
Roche, P ;
van Deursen, JM .
NATURE GENETICS, 2004, 36 (07) :744-749
[3]   The END network couples spindle pole assembly to inhibition of the anaphase-promoting Complex/Cyclosome in early mitosis [J].
Ban, Kenneth H. ;
Torres, Jorge Z. ;
Miller, Julie J. ;
Mikhailov, Alexei ;
Nachury, Maxence V. ;
Tung, Jeffrey J. ;
Rieder, Conly L. ;
Jackson, Peter K. .
DEVELOPMENTAL CELL, 2007, 13 (01) :29-42
[4]   Involvement of the SCF complex in the control of Cdh1 degradation in S-phase [J].
Benmaamar, R ;
Pagano, M .
CELL CYCLE, 2005, 4 (09) :1230-1232
[5]   PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in Drosophila [J].
Benoit, Perrine ;
Papin, Catherine ;
Kwak, Jae Eun ;
Wickens, Marvin ;
Simonelig, Martine .
DEVELOPMENT, 2008, 135 (11) :1969-1979
[6]   Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCFβtrcp [J].
Bernis, Cyril ;
Vigneron, Suzanne ;
Burgess, Andrew ;
Labbe, Jean-Claude ;
Fesquet, Didier ;
Castro, Anna ;
Lorca, Thierry .
EMBO REPORTS, 2007, 8 (01) :91-98
[7]  
Blanco MA, 2001, J CELL SCI, V114, P2135
[8]   APCste9/srw1 promotes degradation of mitotic cyclins in G1 and is inhibited by cdc2 phosphorylation [J].
Blanco, MA ;
Sánchez-Díaz, A ;
de Prada, JM ;
Moreno, S .
EMBO JOURNAL, 2000, 19 (15) :3945-3955
[9]   Flies without a spindle checkpoint [J].
Buffin, Eulalie ;
Emre, Doruk ;
Karess, Roger E. .
NATURE CELL BIOLOGY, 2007, 9 (05) :565-U150
[10]   Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin [J].
Buonomo, SBC ;
Clyne, RK ;
Fuchs, J ;
Loidl, J ;
Uhlmann, F ;
Nasmyth, K .
CELL, 2000, 103 (03) :387-398
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