Phenotypic Heterogeneity in Hidradenitis Suppurativa (Acne Inversa): Classification Is an Essential Step Toward Personalized Therapy

被引：32

作者：

Ingram, John R. ^{[1
]}

Piguet, Vincent ^{[1
]}

机构：

[1] Univ Wales Hosp, Dept Dermatol & Wound Healing, Inst Infect & Immun, Cardiff CF14 4XW, S Glam, Wales

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2013年 / 133卷 / 06期

关键词：

NCSTN MUTATIONS; PSENEN; GENE;

D O I：

10.1038/jid.2012.476

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Awareness is increasing that there is phenotypic heterogeneity within the hidradenitis suppurativa (HS) disease spectrum. However, the few randomized HS trials that are available have not distinguished between the subtypes of the disease. In this issue, Canoui-Poitrine et al. used latent class (LC) analysis of the largest HS cohort described to date to generate three phenotypic subtypes. LC 1 correlates with "typical" European HS, mainly involving the axilla, groin, and, in women, the inframammary region. "Atypical" HS, which may be linked to c-secretase gene mutations, was subdivided further into LC2 and LC3 subtypes.

引用

页码：1453 / 1456

页数：4

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