The assessment of the relationship between variations in the apelin gene and coronary artery disease in Turkish population

被引:2
作者
Pakizeh, Ebrahim [1 ]
Coskunpinar, Ender [2 ]
Oltulu, Yasemin Musteri [2 ]
Cakmak, Huseyin Altug [1 ]
Ikitimur, Baris [1 ]
Saglam, Zumrut Mine Isik [2 ]
Karimova, Ayla [2 ]
Vural, Vural Ali [1 ]
机构
[1] Istanbul Univ, Dept Cardiol, Cerrahpasa Med Fac, Istanbul, Turkey
[2] Istanbul Univ, Dept Mol Med, Inst Expt Med, Istanbul, Turkey
关键词
apelin; single nucleotide polymorphism; coronary artery disease; PEPTIDE APELIN; POLYMORPHISMS; GUIDELINES; MANAGEMENT; LIGAND; RISK;
D O I
10.5152/akd.2014.5685
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Apelin is a novel endogenous peptide with inotropic and vasodilatory properties and is the ligand for the angiotensin receptor-like 1 (APJ) receptor. The aim of the study was to investigate the association of 2 single-nucleotide polymorphisms (SNPs) in the apelin gene with susceptibility to coronary artery disease (CAD) in the Turkish population. Methods: The present observational case-control study consisted of 244 subjects (134 angiographically proven CAD patients and 110 healthy controls) aged 30-65 years. The association of 2 SNPs (rs3115758 and rs3115759) in the apelin gene and CAD risk was investigated. Real-time polymerase chain reaction (RT-PCR) was used to analyze the 2 SNPs in both the CAD and the healthy subjects. Allele and genotype frequencies between patients and control groups were compared using the Chi-square (chi(2)) test. The relationships of the 2 polymorphisms with the presence of CAD were determined with multiple binary logistic regression analysis after adjustment for CAD risk factors. Results: TT and AA risk genotypes of the rs3115758 and rs3115759 variants in the apelin gene were found to be significantly related with the risk of CAD with the same power (OR: 6.36, 95% CI: 1.41-28.6) (p=0.007). After adjustments for traditional CAD risk factors, the homozygous TT genotype for rs3115758 and AA genotype for rs3115759 increased the CAD risk, both with an OR of 5.91. Conclusion: Genetic variants in the apelin gene are significantly associated with the risk of CAD in the Turkish population.
引用
收藏
页码:716 / 721
页数:6
相关论文
共 24 条
  • [1] Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    Alberti, K. G. M. M.
    Eckel, Robert H.
    Grundy, Scott M.
    Zimmet, Paul Z.
    Cleeman, James I.
    Donato, Karen A.
    Fruchart, Jean-Charles
    James, W. Philip T.
    Loria, Catherine M.
    Smith, Sidney C., Jr.
    [J]. CIRCULATION, 2009, 120 (16) : 1640 - 1645
  • [2] [Anonymous], ENDOCR PRACT, DOI [10.4158/EP.8.6.439, DOI 10.4158/EP.8.6.439]
  • [3] [Anonymous], 1994, POLITIKA
  • [4] [Anonymous], CIRCULATION S1
  • [5] Apelin, a newly identified adipokine up-regulated by insulin and obesity
    Boucher, J
    Masri, B
    Daviaud, D
    Gesta, S
    Guigné, C
    Mazzucotelli, A
    Castan-Laurell, I
    Tack, I
    Knibiehler, B
    Carpéné, C
    Audigier, Y
    Saulnier-Blache, JS
    Valet, P
    [J]. ENDOCRINOLOGY, 2005, 146 (04) : 1764 - 1771
  • [6] A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease
    Chen, Zhong
    Qian, Qi
    Ma, Genshan
    Wang, Jiahong
    Zhang, Xiaoli
    Feng, Yi
    Shen, Chengxing
    Yao, Yuyu
    [J]. MOLECULAR BIOLOGY REPORTS, 2009, 36 (05) : 889 - 893
  • [7] Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure
    Chong, KS
    Gardner, RS
    Morton, JJ
    Ashley, EA
    McDonagh, TA
    [J]. EUROPEAN JOURNAL OF HEART FAILURE, 2006, 8 (04) : 355 - 360
  • [8] APJ polymorphisms in coronary artery disease patients with and without hypertension
    Falcone, Colomba
    Bozzini, Sara
    Schirinzi, Sandra
    Buzzi, Maria Paola
    Boiocchi, Chiara
    Totaro, Rossana
    Bondesan, Marialisa
    Pelissero, Gabriele
    [J]. MOLECULAR MEDICINE REPORTS, 2012, 5 (02) : 321 - 325
  • [9] Vascular effects of apelin in vivo in man
    Japp, Alan G.
    Cruden, Nicholas L.
    Amer, David A. B.
    Li, Vivienne K. Y.
    Goudie, Ewan B.
    Johnston, Neil R.
    Sharma, Sushma
    Neilson, Ilene
    Webb, David J.
    Megson, Ian L.
    Flapan, Andrew D.
    Newby, David E.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (11) : 908 - 913
  • [10] Interactive Association of Five Candidate Polymorphisms in Apelin/APJ Pathway with Coronary Artery Disease among Chinese Hypertensive Patients
    Jin, Wei
    Su, Xiuxiu
    Xu, Min
    Liu, Yan
    Shi, Jingyi
    Lu, Lin
    Niu, Wenquan
    [J]. PLOS ONE, 2012, 7 (12):