Recent developments on polysaccharide-based chiral stationary phases for liquid-phase separation of enantiomers

被引：414

作者：

Chankvetadze, Bezhan ^{[1
]}

机构：

[1] Tbilisi State Univ, Sch Exact & Nat Sci, Inst Phys & Analyt Chem, Chavchavadze Ave 1, GE-0179 Tbilisi, Georgia

来源：

JOURNAL OF CHROMATOGRAPHY A | 2012年 / 1269卷

关键词：

Chiral separations; Polysaccharide-based chiral stationary phases; High-performance liquid chromatography; Nano-liquid chromatography; Capillary electrochromatography; Super/sub-critical fluid chromatography; Separation mechanisms; Review; SUPERCRITICAL-FLUID CHROMATOGRAPHY; VALIDATED LC METHOD; MOVING-BED CHROMATOGRAPHY; PROFEN ACID ENANTIOMERS; S-TIMOLOL MALEATE; SOLID-STATE NMR; ENANTIOSELECTIVE ANALYSIS; ELUTION ORDER; MOBILE-PHASE; SILICA-GEL;

D O I：

10.1016/j.chroma.2012.10.033

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper summarizes recent developments in the synthesis, application and mechanistic studies on polysaccharide-based chiral stationary phases (CSPs) for liquid phase separation techniques. Together with applications in conventional high-performance liquid chromatography (HPLC) applications in nano-liquid chromatography (nano-LC), capillary electrochromatography (CEC), super/sub-critical fluid chromatography (SFC) and preparative and product scale separations are also summarized. In the final part of the overview mechanistic aspects and some unusual effects observed in HPLC with these materials are shortly discussed and the author's view regarding future trends in this field is provided. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：26 / 51

页数：26

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