Biology of Bone Sarcomas and New Therapeutic Developments

被引：125

作者：

Brown, Hannah K. ^{[1
,5
]}

Schiavone, Kristina ^{[1
,5
]}

Gouin, Francois ^{[2
,3
]}

Heymann, Marie-Francoise ^{[1
,4
,5
]}

Heymann, Dominique ^{[1
,3
,4
,5
]}

机构：

[1] Univ Sheffield, Med Sch, Dept Oncol & Metab, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England

[2] INSERM, UMR1238, Fac Med, European Associated Lab,Sarcoma Res Unit, Nantes, France

[3] Univ Nantes, Fac Med, F-44035 Nantes, France

[4] INSERM, UMR 1232, Inst Cancerol Ouest, Site Rene Gauducheau, F-44805 St Herblain, France

[5] Univ Sheffield, INSERM, Med Sch, European Associated Lab,Sarcoma Res Unit, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England

来源：

CALCIFIED TISSUE INTERNATIONAL | 2018年 / 102卷 / 02期

关键词：

Osteosarcoma; Ewing sarcoma; Chondrosarcoma; Giant cell tumour of bone; Tumour microenvironment; Immunotherapy; Clinical trials; GIANT-CELL TUMOR; ZOLEDRONIC ACID; EWINGS-SARCOMA; STEM-CELLS; OSTEOSARCOMA CELLS; MTOR INHIBITION; MOUSE MODELS; OPEN-LABEL; CHONDROSARCOMA; EXPRESSION;

D O I：

10.1007/s00223-017-0372-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis. This review gives a brief overview of their specificities and summarises the main therapeutic advances in the field of bone sarcoma.

引用

页码：174 / 195

页数：22

共 145 条

[1] Bone microenvironment signals in osteosarcoma development [J].

Alfranca, Arantzazu ;

Martinez-Cruzado, Lucia ;

Tornin, Juan ;

Abarrategi, Ander ;

Amaral, Teresa ;

de Alava, Enrique ;

Menendez, Pablo ;

Garcia-Castro, Javier ;

Rodriguez, Rene .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 72 (16) :3097-3113

[2] PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome [J].

Alsaab, Hashem O. ;

Sau, Samaresh ;

Alzhrani, Rami ;

Tatiparti, Katyayani ;

Bhise, Ketki ;

Kashaw, Sushil K. ;

Iyer, Arun K. .

FRONTIERS IN PHARMACOLOGY, 2017, 8

[3] IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours [J].

Amary, M. Fernanda ;

Bacsi, Krisztian ;

Maggiani, Francesca ;

Damato, Stephen ;

Halai, Dina ;

Berisha, Fitim ;

Pollock, Robin ;

O'Donnell, Paul ;

Grigoriadis, Anita ;

Diss, Tim ;

Eskandarpour, Malihe ;

Presneau, Nadege ;

Hogendoorn, Pancras C. W. ;

Futreal, Andrew ;

Tirabosco, Roberto ;

Flanagan, Adrienne M. .

JOURNAL OF PATHOLOGY, 2011, 224 (03) :334-343

[4] Population-based study of giant cell tumor of bone in Sweden (1983-2011) [J].

Amelio, Justyna M. ;

Rockberg, Julia ;

Hernandez, Rohini K. ;

Sobocki, Patrik ;

Stryker, Scott ;

Bach, Bruce A. ;

Engellau, Jacob ;

Liede, Alexander .

CANCER EPIDEMIOLOGY, 2016, 42 :82-89

[5]

[Anonymous], 2016, MED ONCOL

[6] Clinical activity of pazopanib in metastatic extraosseous Ewing sarcoma [J].

Attia, Steven ;

Okuno, Scott H. ;

Robinson, Steven I. ;

Webber, Nicholas P. ;

Indelicato, Daniel J. ;

Jones, Robin L. ;

Bagaria, Sanjay P. ;

Sherman, Courtney ;

Kozak, Kevin R. ;

Cortese, Cherise M. ;

McFarland, Thomas ;

Trent, Jonathan C. ;

Maki, Robert G. .

RARE TUMORS, 2015, 7 (02) :86-88

[7] Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation [J].

Avnet, Sofia ;

Di Pompo, Gemma ;

Chano, Tokuhiro ;

Errani, Costantino ;

Ibrahim-Hashim, Arig ;

Gillies, Robert J. ;

Donati, Davide Maria ;

Baldini, Nicola .

INTERNATIONAL JOURNAL OF CANCER, 2017, 140 (06) :1331-1345

[8] Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression [J].

Baglio, S. Rubina ;

Lagerweij, Tonny ;

Perez-Lanzon, Maria ;

Ho, Xuan Dung ;

Leveille, Nicolas ;

Melo, Sonia A. ;

Cleton-Jansen, Anne-Marie ;

Jordanova, Ekaterina S. ;

Roncuzzi, Laura ;

Greco, Michelina ;

van Eijndhoven, Monique A. J. ;

Grisendi, Giulia ;

Dominici, Massimo ;

Bonafede, Roberta ;

Lougheed, Sinead M. ;

de Gruijl, Tanja D. ;

Zini, Nicoletta ;

Cervo, Silvia ;

Steffan, Agostino ;

Canzonieri, Vincenzo ;

Martson, Aare ;

Maasalu, Katre ;

Koks, Sulev ;

Wurdinger, Tom ;

Baldini, Nicola ;

Pegtel, D. Michiel .

CLINICAL CANCER RESEARCH, 2017, 23 (14) :3721-3733

[9] Micro-Environmental Stress Induces Src-Dependent Activation of Invadopodia and Cell Migration in Ewing Sarcoma [J].

Bailey, Kelly M. ;

Airik, Merlin ;

Krook, Melanie A. ;

Pedersen, Elisabeth A. ;

Lawlor, Elizabeth R. .

NEOPLASIA, 2016, 18 (08) :480-488

[10] Ewing's sarcoma [J].

Balamuth, Naomi J. ;

Womer, Richard B. .

LANCET ONCOLOGY, 2010, 11 (02) :184-192

← 1 2 3 4 5 6 7 8 9 10 →