Romiplostim efficacy in an acute myeloid leukemia patient with transfusion refractory thrombocytopenia

被引：7

作者：

Berthelot-Richer, Maxime

Boilard, Brigitte

Morin, Annie

Bolduc, Brigitte

Beauregard, Patrice

Kotb, Rami

机构：

[1] Ctr Hosp Univ Sherbrooke, Div Hematol & Clin Pharm, Sherbrooke, PQ, Canada

[2] Etienne Le Bel Clin Res Ctr, Sherbrooke, PQ, Canada

来源：

TRANSFUSION | 2012年 / 52卷 / 04期

关键词：

RISK MYELODYSPLASTIC SYNDROME; THROMBOPOIETIN; PURPURA; SAFETY; AGENTS;

D O I：

10.1111/j.1537-2995.2011.03382.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Refractoriness to platelet (PLT) transfusion is a feared, life-threatening complication in hematology-oncology patients. Despite increased PLT requirement and treatment costs, the clinical management is difficult and these patients had less favorable outcomes. CASE REPORT: We report on the efficacy of the thrombopoietic agent romiplostim in a patient with acute myeloid leukemia with chemotherapy-induced transfusion-refractory thrombocytopenia. CONCLUSION: Romiplostim could be very helpfull in the management of AML patients with transfusion refractory thrombocytopenia.

引用

页码：739 / 741

页数：3

共 17 条

[1] Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP [J].

Bussel, James B. ;

Kuter, David J. ;

Pullarkat, Vinod ;

Lyons, Roger M. ;

Guo, Matthew ;

Nichol, Janet L. .

BLOOD, 2009, 113 (10) :2161-2171

[2] Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia [J].

Corazza, F ;

Hermans, C ;

D'Hondt, S ;

Ferster, A ;

Kentos, A ;

Benoît, Y ;

Sariban, E .

BLOOD, 2006, 107 (06) :2525-2530

[3] Efficacy of Romiplostim in the Treatment of Chemotherapy Induced Thrombocytopenia (CIT) in a Patient with Mantle Cell Lymphoma [J].

Demeter, Judit ;

Istenes, Ildiko ;

Fodor, Aniko ;

Paksi, Melinda ;

Dombi, Peter ;

Valasinyoszki, Erika ;

Csomor, Judit ;

Matolcsy, Andras ;

Nagy, Zsolt G. .

PATHOLOGY & ONCOLOGY RESEARCH, 2011, 17 (01) :141-143

[4] Safety and Efficacy of Romiplostim in Patients With Lower-Risk Myelodysplastic Syndrome and Thrombocytopenia [J].

Kantarjian, Hagop ;

Fenaux, Pierre ;

Sekeres, Mikkael A. ;

Becker, Pamela S. ;

Boruchov, Adam ;

Bowen, David ;

Hellstrom-Lindberg, Eva ;

Larson, Richard A. ;

Lyons, Roger M. ;

Muus, Petra ;

Shammo, Jamile ;

Siegel, Robert ;

Hu, Kuolung ;

Franklin, Janet ;

Berger, Dietmar P. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (03) :437-444

[5] Phase 2 study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy [J].

Kantarjian, Hagop M. ;

Giles, Francis J. ;

Greenberg, Peter L. ;

Paquette, Ron L. ;

Wang, Eunice S. ;

Gabrilove, Janice L. ;

Garcia-Manero, Guillermo ;

Hu, Kuolung ;

Franklin, Janet L. ;

Berger, Dietmar P. .

BLOOD, 2010, 116 (17) :3163-3170

[6] The clinical impact of platelet refractoriness: correlation with bleeding and survival [J].

Kerkhoffs, Jean-Louis H. ;

Eikenboom, Jeroen Q. ;

van de Watering, Leo M. G. ;

van Wordragen-Vlaswinkel, Riniel ;

Wijermans, Pierre W. ;

Brand, Anneke .

TRANSFUSION, 2008, 48 (09) :1959-1965

[7] Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura:: a double-blind randomised controlled trial [J].

Kuter, David J. ;

Bussel, James B. ;

Lyons, Roger M. ;

Pullarkat, Vinod ;

Gernsheimer, Terry B. ;

Senecal, Francis M. ;

Aledort, Louis M. ;

George, James N. ;

Kessler, Craig M. ;

Sanz, Miguel A. ;

Liebman, Howard A. ;

Slovick, Frank T. ;

de Wolf, J. Th M. ;

Bourgeois, Emmanuelle ;

Guthrie, Troy H., Jr. ;

Newland, Adrian ;

Wasser, Jeffrey S. ;

Hamburg, Solomon I. ;

Grande, Carlos ;

Lefrere, Francois ;

Lichtin, Alan Eli ;

Tarantino, Michael D. ;

Terebelo, Howard R. ;

Viallard, Jean-Francois ;

Cuevas, Francis J. ;

Go, Ronald S. ;

Henry, David H. ;

Redner, Robert L. ;

Rice, Lawrence ;

Schipperus, Martin R. ;

Guo, D. Matthew ;

Nichol, Janet L. .

LANCET, 2008, 371 (9610) :395-403

[8] Biology and Chemistry of Thrombopoietic Agents [J].

Kuter, David J. .

SEMINARS IN HEMATOLOGY, 2010, 47 (03) :243-248

[9]

Lam Masha S H, 2010, J Oncol Pharm Pract, V16, P89, DOI 10.1177/1078155209337668

[10] Subcutaneous or Intravenous Administration of Romiplostim in Thrombocytopenic Patients With Lower Risk Myelodysplastic Syndromes [J].

Sekeres, Mikkael A. ;

Kantarjian, Hagop ;

Fenaux, Pierre ;

Becker, Pamela ;

Boruchov, Adam ;

Guerci-Bresler, Agnes ;

Hu, Kuolung ;

Franklin, Janet ;

Wang, Yow-Ming C. ;

Berger, Dietmar .

CANCER, 2011, 117 (05) :992-1000

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