History of meningococcal vaccines and their serological correlates of protection

被引:52
作者
Vipond, Caroline [1 ]
Care, Rory [1 ]
Feavers, Ian M. [1 ]
机构
[1] NIBSC, Div Bacteriol, Potters Bar EN6 3QG, Herts, England
关键词
Vaccine; Meningitis; Polysaccharide; Outer membrane vesicle; Serological correlate; Complement; Bactericidal antibody; Gene expression; OUTER-MEMBRANE PROTEIN; C CONJUGATE VACCINE; MENINGITIDIS GROUP-B; FACTOR-H BINDING; NEISSERIA-MENINGITIDIS; SEROGROUP-C; GROUP-A; IMMUNE-RESPONSE; VESICLE VACCINE; POLYSACCHARIDE VACCINE;
D O I
10.1016/j.vaccine.2011.12.060
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
For over a hundred years Neisseria meningitidis has been known to be one of the major causes of bacterial meningitis. However, effective vaccines were not developed until the latter part of the 20th century. The first of these were based on purified high molecular weight capsular polysaccharides and more recently the development of glycoconjugate vaccines has made paediatric immunisation programmes possible. The prevention of group B meningococcal disease has remained a challenge throughout this period. This review charts the history of the development of meningococcal vaccines and the importance of serological correlates of protection in their evaluation. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:B10 / B17
页数:8
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