Kinetic proofreading of gene activation by chromatin remodeling

被引：29

作者：

Blossey, R. ^{[1
]}

Schiessel, H. ^{[2
]}

机构：

[1] Lille Univ Sci & Technol, CNRS, IEMN UMR 8520, Interdisciplinary Res Inst,USR 3078, F-59652 Villeneuve Dascq, France

[2] Leiden Univ, Inst Lorentz, NL-2300 RA Leiden, Netherlands

来源：

HFSP JOURNAL | 2008年 / 2卷 / 03期

关键词：

D O I：

10.2976/1.2909080

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gene activation in eukaryotes involves the concerted action of histone tail modifiers, chromatin remodelers, and transcription factors, whose precise coordination is currently unknown. We demonstrate that the experimentally observed interactions of the molecules are in accord with a kinetic proofreading scheme. Our finding could provide a basis for the development of quantitative models for gene regulation in eukaryotes based on the combinatorical interactions of chromatin modifiers.

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页码：167 / 170

页数：4

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