Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease

被引：8

作者：

Kang, Min-Kyung ^{[2
]}

Chang, Hyuk-Jae ^{[1
]}

Kim, Young Jin ^{[3
]}

Park, Ae Ran ^{[4
]}

Park, Sungha ^{[1
]}

Jang, Yangsoo ^{[1
]}

Chung, Namsik ^{[1
]}

机构：

[1] Yonsei Univ Hlth Syst, Severance Cardiovasc Hosp, Div Cardiol, Seoul 120752, South Korea

[2] Hallym Univ, Med Ctr, Div Cardiol, Dept Internal Med,Kangnam Sacred Heart Hosp, Seoul, South Korea

[3] Yonsei Univ Hlth Syst, Severance Cardiovasc Hosp, Div Radiol, Seoul 120752, South Korea

[4] Yonsei Univ, Coll Med, Dept Res Affairs, Seoul, South Korea

来源：

CORONARY ARTERY DISEASE | 2012年 / 23卷 / 03期

关键词：

premature coronary artery disease; 64-slice multi-detector computed tomography; urinary albumin excretion; C-REACTIVE PROTEIN; LOW-GRADE ALBUMINURIA; FAMILY-HISTORY; HEART-DISEASE; MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE; RISK-FACTOR; ASYMPTOMATIC ADULTS; PARENTAL HISTORY; PANEL III;

D O I：

10.1097/MCA.0b013e3283515538

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background This study aimed to investigate the prevalence of subclinical coronary artery disease (CAD) in first-degree relatives (FDRs) with premature CAD and its associating factors other than conventional risk factors. Methods A total of 122 FDRs (58 men, 50 +/- 7 years) of patients with premature CAD were enrolled. The individuals who had undergone health checkups were included in the control group. Multidetector coronary computed tomography was performed to detect subclinical CAD. Results The prevalence of subclinical CAD (35 vs. 14%, P < 0.001) and at least 50% subclinical CAD (16 vs. 2.5%, P < 0.001) was higher in FDRs than that in the control group. In conditional regression analysis, the urinary albumin-creatinine ratio showed a significant interaction with CAD in FDRs than the control (odds ratio 1.063, 95% confidence interval 1.009-1.118, P = 0.021). Conclusion FDRs of premature CAD are more prevalent in subclinical CAD independent of conventional risk factors. Urinary albumin-creatinine ratio may have an interaction with the development of subclinical CAD in FDRs of premature CAD. Coron Artery Dis 23:167-173 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：167 / 173

页数：7

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