Accelerated partial breast irradiation for suitable elderly women using a single fraction of multicatheter interstitial high-dose-rate brachytherapy: Early results of the Single-Fraction Elderly Breast Irradiation (SiFEBI) Phase I/II trial

被引：33

作者：

Hannoun-Levi, Jean-Michel ^{[1
]}

Kee, Daniel Lam Cham ^{[1
]}

Gal, Jocelyn ^{[2
]}

Schiappa, Renaud ^{[2
]}

Hannoun, Arthur ^{[3
]}

Gautier, Mathieu ^{[1
]}

Boulahssass, Rabia ^{[4
]}

Peyrottes, Isabelle ^{[5
]}

Barranger, Emmanuel ^{[6
]}

Ferrero, Jean-Marc ^{[7
]}

Chand, Marie-Eve ^{[1
]}

Doyen, Jerome ^{[1
]}

机构：

[1] Univ Cote dAzur, Antoine Lacassagne Canc Ctr, Dept Radiat Oncol, 33 Ave Valombrose, F-06107 Nice, France

[2] Univ Cote dAzur, Biostat Unit, Antoine Lacassagne Canc Ctr, Nice, France

[3] Univ Cote dAzur, Lycee Massena, Nice, France

[4] Univ Cote dAzur, FHU ONCOAGE, CHU Nice, Geriatr Unit, Nice, France

[5] Univ Cote dAzur, Dept Pathol, Antoine Lacassagne Canc Ctr, Nice, France

[6] Univ Cote dAzur, Dept Breast Surg, Antoine Lacassagne Canc Ctr, Nice, France

[7] Univ Cote dAzur, Dept Med Oncol, Antoine Lacassagne Canc Ctr, Nice, France

来源：

BRACHYTHERAPY | 2018年 / 17卷 / 02期

关键词：

Breast cancer; Elderly women; Single fraction; Accelerated partial breast irradiation; Brachytherapy; INTRAOPERATIVE RADIATION-THERAPY; IN-SITU CARCINOMA; CONSERVING SURGERY; RANDOMIZED-TRIAL; FEMALE BREAST; CANCER; RADIOTHERAPY; TOXICITY; UPDATE; SYSTEM;

D O I：

10.1016/j.brachy.2017.11.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PURPOSE/OBJECTIVE: To evaluate feasibility and early clinical outcomes of a single fraction of multi-catheter interstitial high-dose rate brachytherapy for accelerated partial breast irradiation (APBI) in the elderly. MATERIAL/METHODS: From November 2012 to September 2014, 26 patients (>= 70) with early breast cancer were enrolled in a prospective phase II trial (NCT01727011). After lumpectomy, intra-operative catheter implant was performed for post-operative APBI (single fraction 16 Gy). Surveillance was achieved at 1, 3 and 6 months after APBI, then twice a year. Acute toxicity was investigated. Early cosmetic outcome was analyzed (patient, radiation oncologist, 2 observers). Local and regional relapse-free survival, cancer specific survival and overall survival were analyzed. RESULTS: Median age was 77 years [69-89]. Median CTV was 41 cc [22-95]. Acute toxicity was observed in 18 pts (70%) with a total of 44 events: Gl: 75.7%; G2: 22.8%; G3: 4.5%. Breast fibrosis (31.8%), puncture site inflammation (13.6%) and skin hyperpigmentation (11.4%) were the most frequent side effects. Cosmetic evaluation at 6 months was excellent/good in 88%, 92%, 85% and 88% for patient, radiation oncologist, observer #1 and #2 respectively. With a median follow-up of 37.2 months [35.6-42.3], side effects were G1: 4 pts (15%) and G2: 1 pt (4%). Three-year Local and regional relapse-free survival, cancer specific survival and overall survival rates were 100%, 100%, 100% and 95.2% respectively. CONCLUSIONS: For elderly early breast cancer, a post-operative multi-catheter interstitial high-dose rate brachytherapy single dose (16 Gy) appears feasible. Acute toxicity is acceptable as well as early cosmetic outcome. Oncologic outcome seems encouraging and allows going forward with new clinical trials focusing on single fraction APBI. (C) 2017 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

引用

页码：407 / 414

页数：8

共 29 条

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