Choline and betaine ameliorate liver lipid accumulation induced by vitamin B6 deficiency in rats

被引：11

作者：

Kitagawa, Erina ^{[1
,2
]}

Yamamoto, Tatsuya ^{[3
]}

Fujishita, Mayuko ^{[3
]}

Ota, Yuki ^{[3
]}

Yamamoto, Kohei ^{[1
]}

Nakagawa, Tomoyuki ^{[1
,3
,4
]}

Hayakawa, Takashi ^{[1
,3
,4
]}

机构：

[1] Gifu Univ, United Grad Sch Agr Sci, Gifu, Japan

[2] Nagoya Bunri Univ, Fac Hlth & Human Life, Inazawa, Japan

[3] Gifu Univ, Grad Sch Appl Biol Sci, Gifu, Japan

[4] Gifu Univ, Fac Appl Biol Sci, Gifu, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2017年 / 81卷 / 02期

关键词：

vitamin B-6 deficiency; liver lipids; choline; betaine; methionine metabolism; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; DENSITY LIPOPROTEIN SECRETION; S-ADENOSYLHOMOCYSTEINE; PHOSPHATIDYLCHOLINE BIOSYNTHESIS; ADENOSYLMETHIONINE; METHIONINE; ACID; DIET; REQUIREMENT; METHYLATION;

D O I：

10.1080/09168451.2016.1240604

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the efficacy of supplementing the diet with choline or betaine in ameliorating lipid accumulation induced by vitamin B-6 (B-6) deficiency in rat liver. Male Wistar rats were fed a control, B-6-deficient, choline-supplemented (2, 4, or 6g choline bitartrate/kg diet) B-6-deficient diet or betaine-supplemented (1, 2, or 4g betaine anhydrous/kg diet) B-6-deficient diet for 35 d; all diets contained 9g L-methionine (Met)/kg diet. Choline or betaine supplementation attenuated liver lipid deposition and restored plasma lipid profiles to control levels. These treatments restored the disruptions in Met metabolism and the phosphatidylcholine (PC)/phosphatidylethanolamine (PE) ratio induced by B-6 deficiency in liver microsomes. These results suggest that choline and betaine ameliorated liver lipid accumulation induced by B-6 deficiency via recovery of Met metabolism and very low-density lipoprotein secretion by restoring the supply of PC derived from PE.

引用

页码：316 / 322

页数：7

共 35 条

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