IL2RB maintains immune harmony

被引：16

作者：

Campbell, Tessa M. ^{[1
]}

Bryceson, Yenan T. ^{[1
]}

机构：

[1] Karolinska Inst, Dept Med, Ctr Regenerat Med, Stockholm, Sweden

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2019年 / 216卷 / 06期

关键词：

MICE LACKING; T-CELLS; MUTATION; IMMUNODEFICIENCY; EXPRESSION; CHAIN; FOXP3;

D O I：

10.1084/jem.20190546

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How the IL-2 receptor beta-chain specifically shapes immunity has remained enigmatic. In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20182304) and Fernandez et al. (https://doi.org/10.1084/jem.20182015) independently report the first observations of autosomal recessive mutations in IL2RB, revealing a requirement for IL2RB in immunity and peripheral immune tolerance.

引用

页码：1231 / 1233

页数：3

共 15 条

[1] CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes [J].

Caudy, Amy A. ;

Reddy, Sreelatha T. ;

Chatila, Talal ;

Atkinson, John P. ;

Verbsky, James W. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (02) :482-487

[2]

Fernandez IZ, 2019, J EXP MED, V216, P1255, DOI 10.1084/jem.20182015

[3] Defective expression of the interleukin-2/interleukin-15 receptor β subunit leads to a natural killer cell-deficient form of severe combined immunodeficiency [J].

Gilmour, KC ;

Fujii, H ;

Cranston, T ;

Davies, EG ;

Kinnon, C ;

Gaspar, HB .

BLOOD, 2001, 98 (03) :877-879

[4] Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity [J].

Goudy, Kevin ;

Aydin, Didem ;

Barzaghi, Federica ;

Gambineri, Eleonora ;

Vignoli, Marina ;

Mannurita, Sara Ciullini ;

Doglioni, Claudio ;

Ponzoni, Maurilio ;

Cicalese, Maria Pia ;

Assanelli, Andrea ;

Tommasini, Alberto ;

Brigida, Immacolata ;

Dellepiane, Rosa Maria ;

Martino, Silvana ;

Olek, Sven ;

Aiuti, Alessandro ;

Ciceri, Fabio ;

Roncarolo, Maria Grazia ;

Bacchetta, Rosa .

CLINICAL IMMUNOLOGY, 2013, 146 (03) :248-261

[5] Novel pathogenic variants in FOXP3 in fetuses with echogenic bowel and skin desquamation identified by ultrasound [J].

Louie, Raymond J. ;

Tan, Queenie K. -G. ;

Gilner, Jennifer B. ;

Rogers, R. Curtis ;

Younge, Noelle ;

Wechsler, Stephanie B. ;

McDonald, Marie T. ;

Gordon, Barbara ;

Saski, Christopher A. ;

Jones, Julie R. ;

Chapman, Shelley J. ;

Stevenson, Roger E. ;

Sleasman, John W. ;

Friez, Michael J. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2017, 173 (05) :1219-1225

[6] Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero [J].

Mold, Jeff E. ;

Michaelsson, Jakob ;

Burt, Trevor D. ;

Muench, Marcus O. ;

Beckerman, Karen P. ;

Busch, Michael P. ;

Lee, Tzong-Hae ;

Nixon, Douglas F. ;

McCune, Joseph M. .

SCIENCE, 2008, 322 (5907) :1562-1565

[7] Immunological Tolerance During Fetal Development: From Mouse to Man [J].

Mold, Jeff E. ;

McCune, Joseph M. .

ADVANCES IN IMMUNOLOGY, VOL 115, 2012, 115 :73-111

[8] INTERLEUKIN-2 RECEPTOR GAMMA CHAIN MUTATION RESULTS IN X-LINKED SEVERE COMBINED IMMUNODEFICIENCY IN HUMANS [J].

NOGUCHI, M ;

YI, HF ;

ROSENBLATT, HM ;

FILIPOVICH, AH ;

ADELSTEIN, S ;

MODI, WS ;

MCBRIDE, OW ;

LEONARD, WJ .

CELL, 1993, 73 (01) :147-157

[9] New insights into the regulation of T cells by γc family cytokines [J].

Rochman, Yrina ;

Spolski, Rosanne ;

Leonard, Warren J. .

NATURE REVIEWS IMMUNOLOGY, 2009, 9 (07) :480-490

[10] Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor [J].

Sharfe, N ;

Dadi, HK ;

Shahar, M ;

Roifman, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (07) :3168-3171

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