IL2RB maintains immune harmony

被引：16

作者：

Campbell, Tessa M. ^{[1
]}

Bryceson, Yenan T. ^{[1
]}

机构：

[1] Karolinska Inst, Dept Med, Ctr Regenerat Med, Stockholm, Sweden

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2019年 / 216卷 / 06期

关键词：

MICE LACKING; T-CELLS; MUTATION; IMMUNODEFICIENCY; EXPRESSION; CHAIN; FOXP3;

D O I：

10.1084/jem.20190546

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How the IL-2 receptor beta-chain specifically shapes immunity has remained enigmatic. In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20182304) and Fernandez et al. (https://doi.org/10.1084/jem.20182015) independently report the first observations of autosomal recessive mutations in IL2RB, revealing a requirement for IL2RB in immunity and peripheral immune tolerance.

引用

页码：1231 / 1233

页数：3

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