Microbial Exposure and Onset of Allergic Diseases - Potential Prevention Strategies?

被引:13
作者
Pfefferle, Petra Ina [1 ,2 ]
Renz, Harald [2 ,3 ]
机构
[1] Mol Diagnost Philipps Univ Marburg, Biomed Res Ctr, Inst Lab Med & Pathobiochem, D-35043 Marburg, Germany
[2] Mol Diagnost Philipps Univ Marburg, Univ Hosp Giessen & Marburg GmbH, UGMLC, Qerman Lung Ctr Lung Res DZL, D-35043 Marburg, Germany
[3] Mol Diagnost Philipps Univ Marburg, Univ Hosp Giessen & Marburg GmbH, Inst Lab Med & Pathobiochem, D-35043 Marburg, Germany
关键词
allergy prevention; bacterial stimuli; Barker hypothesis; hygiene hypothesis; microbiota; PLACEBO-CONTROLLED TRIAL; SCHOOL-AGE-CHILDREN; AIRWAY INFLAMMATION; EARLY-LIFE; EXPERIMENTAL ASTHMA; ATOPIC SENSITIZATION; CHILDHOOD ASTHMA; IMMUNE-RESPONSE; GUT MICROBIOTA; LATIN-AMERICA;
D O I
10.2332/allergolint.13-RAI-0671
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Chronic inflammatory diseases are a major health problem with global dimension. Particularly, the incidence of allergic diseases has been increased tremendously within the last decades. This world-wide trend clearly indicates the demand for new approaches in the investigation of early allergy development. Recent studies underlined the basic postulate of the hygiene hypothesis that early exposure to microbial stimuli plays a crucial role in the prevention of chronic inflammatory conditions in adulthood. There is ample evidence that, both, exogenous microbes and endogenous microbial communities, the human microbiota, shape the developing immune system and might be involved in prevention of pathologic pro-inflammatory trails. According to the Barker hypothesis, epidemiological studies pointed to transmaternal transmission from the mother to the offspring already in prenatal life. Experimental data from murine models support these findings. This state of the art review provides an overview on the current literature and presents new experimental concepts that point out to future application in the prevention of allergic diseases.
引用
收藏
页码:3 / 10
页数:8
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