A Cuprous Oxide Thin Film Non-Enzymatic Glucose Sensor Using Differential Pulse Voltammetry and Other Voltammetry Methods and a Comparison to Different Thin Film Electrodes on the Detection of Glucose in an Alkaline Solution

被引：30

作者：

Dai, Yifan ^{[1
,2
]}

Molazemhosseini, Alireza ^{[3
]}

Abbasi, Kevin ^{[4
]}

Liu, Chung Chiun ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Dept Chem & Biomol Engn, 10900 Euclid Ave, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Ctr Elect Design, 10900 Euclid Ave, Cleveland, OH 44106 USA

[3] Politecn Milan, Dipartimento Chim Mat & Ingn Chim Giulio Natta, Via Mancinelli 7, I-20131 Milan, Italy

[4] Case Western Reserve Univ, Swagelok Ctr Surface Anal Mat, 10900 Euclid Ave, Cleveland, OH 44106 USA

来源：

BIOSENSORS-BASEL | 2018年 / 8卷 / 01期

关键词：

cuprous oxide; non-enzymatic glucose sensor; alkaline solution; differential pulse voltammetry; NEURO-DEGENERATIVE DISORDERS; SINGLE-USE; NANOPARTICLES; BIOSENSOR; OXIDATION; BIOMARKER; SHEETS; PBS;

D O I：

10.3390/bios8010004

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A cuprous oxide (Cu2O) thin layer served as the base for a non-enzymatic glucose sensor in an alkaline medium, 0.1 NaOH solution, with a linear range of 50-200 mg/dL using differential pulse voltammetry (DPV) measurement. An X-ray photoelectron spectroscopy (XPS) study confirmed the formation of the cuprous oxide layer on the thin gold film sensor prototype. Quantitative detection of glucose in both phosphate-buffered saline (PBS) and undiluted human serum was carried out. Neither ascorbic acid nor uric acid, even at a relatively high concentration level (100 mg/dL in serum), interfered with the glucose detection, demonstrating the excellent selectivity of this non-enzymatic cuprous oxide thin layer-based glucose sensor. Chronoamperometry and single potential amperometric voltammetry were used to verify the measurements obtained by DPV, and the positive results validated that the detection of glucose in a 0.1 M NaOH alkaline medium by DPV measurement was effective. Nickel, platinum, and copper are commonly used metals for non-enzymatic glucose detection. The performance of these metal-based sensors for glucose detection using DPV were also evaluated. The cuprous oxide (Cu2O) thin layer-based sensor showed the best sensitivity for glucose detection among the sensors evaluated.

引用

页数：13