S-Nitrosothiols, Nitric Oxide and Proinflammatory Cytokines in Children with Inflammatory Bowel Disease

被引：7

作者：

Kolesov, S. A. ^{[1
]}

Korkotashvili, L. V. ^{[1
]}

Yazykova, A. B. ^{[1
]}

Fedulova, E. N. ^{[1
]}

Tutina, O. A. ^{[1
]}

Tolkacheva, N. I. ^{[1
]}

机构：

[1] Fed State Inst Nizhny Novgorod Res Inst Children, Lab Dept, Nizhnii Novgorod, Russia

来源：

CLINICAL LABORATORY | 2013年 / 59卷 / 9-10期

关键词：

S-nitrosothiols; children; IBD; nitric oxide; cytokines; FATE;

D O I：

10.7754/Clin.Lab.2012.120632

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: The aim of the study was to investigate the levels of S-nitrosothiols (RSNO) in blood serum of children with inflammatory bowel disease (IBD), nonspecific ulcerative colitis (NUC) and Crohn's disease (CD), and correlate the obtained data with the number of total nitric oxide metabolites (NOx) and proinflammatory cytokines (PC). Methods: RSNO and NOx were determined by the Griess method and PC by ELISA. We examined 174 children of both genders aged from 6 to 17 years (mean age - 14 years) including 112 children suffering from IBD and 62 children from the control group. The results were statistically processed using Statistica 6.1. Results: The obtained data show an increased but statistically indistinguishable RSNO number in NUC and CD. We revealed the absence of correlation between RSNO and NO and unidirectional RSNO and PC values. Conclusions: The obtained data of RSNO concentrations in blood serum of children with IBD suggest the participation of RSNO in IBD pathogenesis in children and an indirect correlation of the translation of nitric oxide synthase aberrant activity into RSNO.

引用

页码：953 / 957

页数：5

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