Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

被引：276

作者：

Stucki, David ^{[1
,2
]}

Brites, Daniela ^{[1
,2
]}

Jeljeli, Leila ^{[3
,4
]}

Coscolla, Mireia ^{[1
,2
]}

Liu, Qingyun ^{[5
,6
,7
]}

Trauner, Andrej ^{[1
,2
]}

Fenner, Lukas ^{[1
,2
,8
]}

Rutaihwa, Liliana ^{[1
,2
]}

Borrell, Sonia ^{[1
,2
]}

Luo, Tao ^{[9
]}

Gao, Qian ^{[5
,6
,7
]}

Kato-Maeda, Midori ^{[10
]}

Ballif, Marie ^{[1
,2
,8
]}

Egger, Matthias ^{[8
]}

Macedo, Rita ^{[11
]}

Mardassi, Helmi ^{[4
]}

Moreno, Milagros ^{[12
]}

Tudo Vilanova, Griselda ^{[13
]}

Fyfe, Janet ^{[14
]}

Globan, Maria ^{[14
]}

Thomas, Jackson ^{[15
]}

Jamieson, Frances ^{[16
]}

Guthrie, Jennifer L. ^{[16
]}

Asante-Poku, Adwoa ^{[17
]}

Yeboah-Manu, Dorothy ^{[17
]}

Wampande, Eddie ^{[18
]}

Ssengooba, Willy ^{[18
,19
]}

Joloba, Moses ^{[18
]}

Boom, W. Henry ^{[20
]}

Basu, Indira ^{[21
]}

Bower, James ^{[21
]}

Saraiva, Margarida ^{[22
,23
]}

Vasconcellos, Sidra E. G. ^{[24
]}

Suffys, Philip ^{[24
]}

Koch, Anastasia ^{[25
,26
]}

Wilkinson, Robert ^{[25
,26
,27
,28
]}

Gail-Bekker, Linda ^{[25
,26
]}

Malla, Bijaya ^{[1
,2
]}

Ley, Serej D. ^{[1
,2
,29
]}

Beck, Hans-Peter ^{[1
,2
]}

de Jong, Bouke C. ^{[30
]}

Toit, Kadri ^{[31
]}

Sanchez-Padilla, Elisabeth ^{[32
]}

Bonnet, Maryline ^{[32
]}

Gil-Brusola, Ana ^{[33
]}

Frank, Matthias ^{[34
]}

Beng, Veronique N. Penlap ^{[35
]}

Eisenach, Kathleen ^{[36
]}

Alani, Issam ^{[37
]}

Ndung'u, Perpetual Wangui ^{[38
]}

机构：

[1] Swiss Trop & Publ Hlth Inst, Basel, Switzerland

[2] Univ Basel, Basel, Switzerland

[3] Forschungszentrum Borstel, Borstel, Germany

[4] Univ Tunis El Manar, Inst Pasteur Tunis, Tunis, Tunisia

[5] Fudan Univ, Key Lab Med Mol Virol, Minist Educ, Shanghai, Peoples R China

[6] Fudan Univ, Minist Hlth, Inst Biomed Sci, Shanghai, Peoples R China

[7] Fudan Univ, Inst Med Microbiol, Sch Basic Med Sci, Shanghai, Peoples R China

[8] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland

[9] Sichuan Univ, West China Ctr Med Sci, Sch Basic Med Sci, Laborat Infect & Immun, Chengdu, Peoples R China

[10] Univ Calif San Francisco, Sch Med, San Francisco, CA USA

[11] Lab Saude Publ, Lisbon, Portugal

[12] Hosp Nossa Senhora Paz, Cubal, Angola

[13] Hosp Clin ISGlobal, Microbiol Serv, Barcelona, Spain

[14] Victorian Infect Dis Reference Lab, Melbourne, Vic, Australia

[15] Ifakara Hlth Inst, Bagamoyo, Tanzania

[16] Publ Hlth Ontario, Toronto, ON, Canada

[17] Univ Ghana, Noguchi Mem Inst Med Res, Accra, Ghana

[18] Makerere Univ, Dept Med Microbiol, Kampala, Uganda

[19] Univ Amsterdam, Dept Global Hlth, Amsterdam, Netherlands

[20] Case Western Reserve Univ, Dept Mol Biol & Microbiol, Cleveland, OH 44106 USA

[21] Auckland City Hosp, LabPlus, Auckland, New Zealand

[22] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal

[23] ICVS 3Bs PT Govt Associate Lab, Braga, Portugal

[24] Inst Oswaldo Cruz, Rio De Janeiro, Brazil

[25] Univ Cape Town, Institute Infect Dis & Mol Med, Cape Town, South Africa

[26] Univ Cape Town, Dept Clin Lab Sci, Cape Town, South Africa

[27] Imperial Coll London, Dept Med, London, England

[28] Francis Crick Inst Mill Hill Lab, London, England

[29] Papua New Guinea Inst Med Res, Goroka, Papua N Guinea

[30] Inst Trop Med, Antwerp, Belgium

[31] Tartu Univ Hosp, United Labs, Mycobacteriol, Tartu, Estonia

[32] Epicentre, Dept Clin Res, Paris, France

[33] Univ Hosp La Fe, Dept Microbiol, Valencia, Spain

[34] Univ Tubingen, Inst Trop Med, Tubingen, Germany

[35] Univ Yaounde I, Biotechnol Ctr BTC, Inst Lab TB Res LTR, Yaounde, Cameroon

[36] Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72205 USA

[37] Fac Med Technol, Dept Med Lab Technol, Baghdad, Iraq

[38] Jomo Kenyatta Univ Agr & Technol, Inst Trop Med & Infect Dis ITROMID, Nairobi, Kenya

[39] Aga Khan Univ Hosp, Dept Pathol, Nairobi, Kenya

[40] MRC, Fajara, Gambia

[41] Univ Marien Gouabi, Fdn Congolaise Rech Med, Brazzaville, Rep Congo

[42] Univ Witwatersrand, Right Care & Clin HIV Res Unit, Johannesburg, South Africa

[43] Mbeya Med Res Ctr NIMR MMRC, Natl Inst Med Res, Mbeya, Tanzania

[44] Univ Munich, Med Ctr, Div Infect Dis & Trop Med, Munich, Germany

[45] German Ctr Infect Res DZIF, Munich, Germany

[46] IRCCS, San Raffaele Sci Inst, Emerging Bacterial Pathogens Unit, Milan, Italy

[47] Riga East Univ Hosp, Ctr TB & Lung Dis, Riga, Latvia

[48] Publ Hlth Agcy Sweden, Dept Microbiol, WH0 Supranatl TB Reference Lab, Solna, Sweden

[49] Vilnius Univ, Inst Biotechnol, Dept Immunol & Cell Biol, Vilnius, Lithuania

[50] Schleswig Holstein Univ Hosp, Inst Epidemiol, Kiel, Germany

来源：

NATURE GENETICS | 2016年 / 48卷 / 12期

基金：

瑞士国家科学基金会; 欧洲研究理事会; 美国国家卫生研究院;

关键词：

PAPUA-NEW-GUINEA; GENETIC DIVERSITY; RESISTANT TUBERCULOSIS; ANTIGENIC VARIATION; GENOMIC DIVERSITY; HIV-INFECTION; SOUTH-AFRICA; POPULATION; PATHOGENS; EVOLUTION;

D O I：

10.1038/ng.3704

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.

引用

页码：1535 / 1543

页数：9

共 79 条

[1] Resolving lineage assignation on Mycobacterium tuberculosis clinical isolates classified by spoligotyping with a new high-throughput 3R SNPs based method [J].