Myeloid-derived suppressor cells and the efficacy of CD8+ T-cell immunotherapy

被引：6
|
作者：
Lesokhin, Alexander M. [1 ]
Merghoub, Taha [1 ]
Wolchok, Jedd D. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 02期
关键词：
CCR2; myeloid derived suppressor cells; GM-CSF; immunotherapy; adoptive T-cell transfer; ANTIGEN; INFILTRATION; CANCER;
D O I：
10.4161/onci.22764
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Myeloid-derived suppressor cells (MDSCs) promote immune evasion, a key feature of oncogenesis. The restoration of immunosurveillance by immunomodulatory antibodies improves the survival of a subset of cancer patients. Preclinical studies suggest that the ablation of monocytic MDSCs may be a useful adjunct to available immunotherapeutic strategies against cancer.
引用
收藏
页数：3
相关论文
共 50 条
  • [21] Myeloid-derived suppressor cells: Implication in myeloid malignancies and immunotherapy
    Kapor, Suncica
    Radojkovic, Milica
    Santibanez, Juan F.
    ACTA HISTOCHEMICA, 2024, 126 (5-7)
  • [22] T-cell immunotherapy of allergic disease: the role of CD8+ T cells
    Ogg, Graham S.
    CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 3 (06) : 475 - 479
  • [23] Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+ T-cell activation events
    Schouppe, Elio
    Mommer, Camille
    Movahedi, Kiavash
    Laoui, Damya
    Morias, Yannick
    Gysemans, Conny
    Luyckx, Ariane
    De Baetselier, Patrick
    Van Ginderachter, Jo A.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2013, 43 (11) : 2930 - 2942
  • [24] HPV-associated head and neck cancer is characterized by distinct profiles of CD8+ T cells and myeloid-derived suppressor cells
    Kansy, Benjamin A.
    Wehrs, Tim P.
    Bruderek, Kirsten
    Si, Yu
    Ludwig, Sonja
    Droege, Freya
    Hasskamp, Pia
    Henkel, Uta
    Dominas, Nina
    Hoffmann, Thomas K.
    Horn, Peter A.
    Schuler, Martin
    Gauler, Thomas C.
    Lindemann, Monika
    Lang, Stephan
    Bankfalvi, Agnes
    Brandau, Sven
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2023, 72 (12) : 4367 - 4383
  • [25] Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine
    Srivastava, Minu K.
    Sinha, Pratima
    Clements, Virginia K.
    Rodriguez, Paulo
    Ostrand-Rosenberg, Suzanne
    CANCER RESEARCH, 2010, 70 (01) : 68 - 77
  • [26] Protection against HPV-16-Associated Tumors Requires the Activation of CD8+ Effector Memory T Cells and the Control of Myeloid-Derived Suppressor Cells
    Diniz, Mariana O.
    Sales, Natiely S.
    Silva, Jamile R.
    Ferreira, Luis Carlos S.
    MOLECULAR CANCER THERAPEUTICS, 2016, 15 (08) : 1920 - 1930
  • [27] Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth
    Zhao, Hongyun
    Teng, Da
    Yang, Lifeng
    Xu, Xincheng
    Chen, Jiajia
    Jiang, Tengjia
    Feng, Austin Y.
    Zhang, Yaqing
    Frederick, Dennie T.
    Gu, Lei
    Cai, Li
    Asara, John M.
    di Magliano, Marina Pasca
    Boland, Genevieve M.
    Flaherty, Keith T.
    Swanson, Kenneth D.
    Liu, David
    Rabinowitz, Joshua D.
    Zheng, Bin
    NATURE METABOLISM, 2022, 4 (12) : 1660 - +
  • [28] Immunotherapy Targeting Myeloid-Derived Suppressor Cells (MDSCs) in Tumor Microenvironment
    Gao, Xidan
    Sui, Hongshu
    Zhao, Shang
    Gao, Xingmei
    Su, Yanping
    Qu, Peng
    FRONTIERS IN IMMUNOLOGY, 2021, 11
  • [29] Targeting myeloid-derived suppressor cells to enhance natural killer cell-based immunotherapy
    Joshi, Shweta
    Sharabi, Andrew
    PHARMACOLOGY & THERAPEUTICS, 2022, 235
  • [30] Myeloid-Derived Suppressor Cells: Implications in the Resistance of Malignant Tumors to T Cell-Based Immunotherapy
    Shi, Houhui
    Li, Kai
    Ni, Yanghong
    Liang, Xiao
    Zhao, Xia
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 09
12345