5-ETHOXYMETHYLIDENE-4-THIOXO-2-THIAZOLIDINONE AS VERSATILE BUILDING BLOCK FOR NOVEL BIORELEVANT SMALL MOLECULES WITH THIOPYRANO[2,3-d][1,3]THIAZOLE CORE

被引：25

作者：

Atamanyuk, Dmytro ^{[1
]}

Zimenkovsky, Borys ^{[1
]}

Atamanyuk, Vasyl ^{[1
]}

Lesyk, Roman ^{[1
]}

机构：

[1] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Organ & Bioorgan Chem, UA-79010 Lvov, Ukraine

来源：

SYNTHETIC COMMUNICATIONS | 2014年 / 44卷 / 02期

关键词：

Biological activity; 5-ethoxymethylidene-4-thioxo-2-thiazolidinone; hetero-Diels-Alder reaction; thiopyrano[2,3-d]thiazole; ANTICANCER DRUG SCREEN; BIOLOGICAL-ACTIVITIES; MEDICINAL CHEMISTRY; NORBORNANE MOIETY; DERIVATIVES; MECHANISMS; DISCOVERY; RHODANINE; CANCER;

D O I：

10.1080/00397911.2013.800552

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Ethoxymethylidene-4-thioxo-2-thiazolidinone was studied as versatile core building block in the synthesis of new thiopyrano[2,3-d]thiazole derivatives relevant for medicinal chemistry purposes under hetero-Diels-Alder reaction conditions. Promising compounds (6, 10) were identified among synthesized series with high antitumor and moderate antiviral activity. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

引用

页码：237 / 244

页数：8

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