Context: Cypermethrin (CYP) is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control. The toxicity of CYP is well studied in many organisms.Objective: The aim of present study was to investigate the protective effect of Zizyphus lotus (Zizyp) fruit against neurotoxicity and oxidative stress induced by CYP in mice.Materials and methods: Mice were divided into four groups of six each: groups I and II were used as control and CYP control (20mg/kg body weight). While, groups III was orally treated with Zizyphus lotus fruit (5g/kg body weight) plus CYP (20mg/kg body weight) for 18days. Furthermore, HPLC-ESI-MS-MS (Q-Tof) and GC-MS were used to identify the compounds fraction.Results: Antioxidant enzyme catalase (CAT), neurotoxicity enzyme acetylcholinesterase (AChE) activities and hydrogen peroxide (H2O2)(,) malondialdehyde (MDA) levels were determined in the liver, kidney and heart. CYP caused decreased CAT activity, inhibition of AChE activity and increased the levels of H2O2 and MDA in heart, liver and kidney.Conclusion: Our results indicate that Zizyp fruit is markedly effective in protecting mice against CYP-induced biochemical changes. This protection may be due to its antioxidant property and scavenging ability against active free radicals.
机构:
Univ Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, PakistanUniv Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, Pakistan
Shehzad, S.
Farooq, Z.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, PakistanUniv Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, Pakistan
Farooq, Z.
Tahir, S. K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, PakistanUniv Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, Pakistan
Tahir, S. K.
Masood, M. I.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Anim Sci, Inst Pharmaceut Sci, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, PakistanUniv Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, Pakistan
Masood, M. I.
Anjum, S. M. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Anim Sci, Inst Pharmaceut Sci, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, PakistanUniv Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, Pakistan
Anjum, S. M. M.
Saeed, A. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, PakistanUniv Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, Pakistan
Saeed, A. A.
Yousaf, M. S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, PakistanUniv Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, Pakistan
Yousaf, M. S.
Majeed, K. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, PakistanUniv Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, Pakistan
Majeed, K. A.
Rabbani, I.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, PakistanUniv Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, Pakistan
Rabbani, I.
Basharat, S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, PakistanUniv Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, Pakistan
Basharat, S.
Rehman, H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, PakistanUniv Vet & Anim Sci, Dept Physiol, Syed Abdul Qadir Jilani Out Fall Rd, Lahore 54000, Pakistan
机构:
Indian Vet Res Inst, Div Pharmacol & Toxicol, Bareilly 243122, Uttar Pradesh, IndiaIndian Vet Res Inst, Div Pharmacol & Toxicol, Bareilly 243122, Uttar Pradesh, India
Sankar, Palanisamy
Telang, Avinash G.
论文数: 0引用数: 0
h-index: 0
机构:
Indian Vet Res Inst, Div Pharmacol & Toxicol, Bareilly 243122, Uttar Pradesh, IndiaIndian Vet Res Inst, Div Pharmacol & Toxicol, Bareilly 243122, Uttar Pradesh, India
Telang, Avinash G.
Manimaran, Ayyasamy
论文数: 0引用数: 0
h-index: 0
机构:
Indian Vet Res Inst, Div Pharmacol & Toxicol, Bareilly 243122, Uttar Pradesh, IndiaIndian Vet Res Inst, Div Pharmacol & Toxicol, Bareilly 243122, Uttar Pradesh, India
机构:
Periyar Univ, Dept Biotechnol, Mol Entomol Lab, Salem 11, Tamil Nadu, IndiaPeriyar Univ, Dept Biotechnol, Mol Entomol Lab, Salem 11, Tamil Nadu, India
Karthi, Sengodan
Shivakumar, Muthugoundar Subramanian
论文数: 0引用数: 0
h-index: 0
机构:
Periyar Univ, Dept Biotechnol, Mol Entomol Lab, Salem 11, Tamil Nadu, IndiaPeriyar Univ, Dept Biotechnol, Mol Entomol Lab, Salem 11, Tamil Nadu, India
机构:
China Med Univ, Sch Publ Hlth, Shenyang, Peoples R China
Tianjin Med Univ, Sch Publ Hlth, Tianjin, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Shenyang, Peoples R China
Cao, DeQing
Chen, Nan
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Shenyang, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Shenyang, Peoples R China
Chen, Nan
Zhu, ChunXiao
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Shenyang, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Shenyang, Peoples R China
Zhu, ChunXiao
Zhao, Yue
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Shenyang, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Shenyang, Peoples R China
Zhao, Yue
Liu, Li
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Shenyang, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Shenyang, Peoples R China
Liu, Li
Yang, Jun
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Shenyang, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Shenyang, Peoples R China
Yang, Jun
An, Li
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Shenyang, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Shenyang, Peoples R China
机构:
Faculty of Sciences of Tunis, Department of Biology, Ecology, Biology and Physiology of Aquatic Organisms Laboratory, University of El Manar, TunisFaculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Group of Fundamental and Applied Malacology (LEB/GFAM), University of Carthage, Bizerte
Mhadhbi L.
Trigui El Menif N.
论文数: 0引用数: 0
h-index: 0
机构:
Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Group of Fundamental and Applied Malacology (LEB/GFAM), University of Carthage, BizerteFaculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Group of Fundamental and Applied Malacology (LEB/GFAM), University of Carthage, Bizerte