β2-microglobulin, a uremic toxin with a double meaning

被引：31
作者：
Canaud, B
Morena, M
Cristol, JP
Krieter, D
机构：
[1] Lapeyronie Univ Hosp, Nephrol Dialysis & Intens Care Unit, F-34295 Montpellier, France
[2] Lapeyronie Univ Hosp, Dialysis Res & Training Inst, Montpellier, France
[3] Lapeyronie Univ Hosp, Dept Biochem, Montpellier, France
[4] Univ Wurzburg, Dept Med, Div Nephrol, Wurzburg, Germany
来源：
KIDNEY INTERNATIONAL | 2006年 / 69卷 / 08期
关键词：
D O I：
10.1038/sj.ki.5000389
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
beta M-2 is a strong and independent indicator of hemodialysis patient outcomes and an excellent surrogate for middle molecules, and deserves to be routinely monitored and incorporated into dialysis adequacy targets. beta M-2 has a double meaning, reflecting both dialysis efficacy in terms of solute mass transfer and patient bioactivity. The work of Ward et al. in this issue warrants a study to test the hypothesis that long daily hemodiafiltration treatment would be the optimal renal replacement modality to improve dialysis patient outcomes.
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收藏
页码：1297 / 1299
页数：4
相关论文
共 11 条
[1]  
BERGSTROM J, 1979, CLIN NEPHROL, V11, P229
[2]   FAILURE OF A DAILY HEMOFILTRATION PROGRAM USING A HIGHLY PERMEABLE MEMBRANE TO RETURN BETA-2-MICROGLOBULIN CONCENTRATIONS TO NORMAL IN HEMODIALYSIS-PATIENTS [J].
CANAUD, B ;
ASSOUNGA, A ;
KERR, P ;
AZNAR, R ;
MION, C .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 1992, 7 (09) :924-930
[3]   Dialyzer membrane permeability and survival in hemodialysis patients [J].
Chauveau, P ;
Nguyen, H ;
Combe, C ;
Chêne, G ;
Azar, R ;
Cano, N ;
Canaud, B ;
Fouque, D ;
Laville, M ;
Leverve, X ;
Eng, HR ;
Aparicio, M .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2005, 45 (03) :565-571
[4]   Serum β-2 microglobulin levels predict mortality in dialysis patients:: Results of the HEMO study [J].
Cheung, Alfred K. ;
Rocco, Michael V. ;
Yan, Guofen ;
Leypoldt, John K. ;
Levin, Nathan W. ;
Greene, Tom ;
Agodoa, Lawrence ;
Bailey, James ;
Beck, Gerald J. ;
Clark, William ;
Levey, Andrew S. ;
Ornt, Daniel B. ;
Schulman, Gerald ;
Schwab, Steven ;
Teehan, Brendan ;
Eknoyan, Garabed .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (02) :546-555
[5]   Kinetics of β2-microglobulin and phosphate during hemodialysis:: Effects of treatment frequency and duration [J].
Leypoldt, JK .
SEMINARS IN DIALYSIS, 2005, 18 (05) :401-408
[6]   Change from three times a week on-line hemodiafiltration to short daily on-line hemodiafiltration [J].
Maduell, F ;
Navarro, V ;
Torregrosa, E ;
Rius, A ;
Dicenta, F ;
Cruz, MC ;
Ferrero, JA .
KIDNEY INTERNATIONAL, 2003, 64 (01) :305-313
[7]  
Miyata T, 1998, J AM SOC NEPHROL, V9, P1723
[8]  
Miyata T, 2001, KIDNEY INT, V59, pS25
[9]   Phosphate kinetics during hemodialysis: Evidence for biphasic regulation [J].
Spalding, EM ;
Chamney, PW ;
Farrington, K .
KIDNEY INTERNATIONAL, 2002, 61 (02) :655-667
[10]   New insights in uremic toxins [J].
Vanholder, R ;
Glorieux, G ;
De Smet, R ;
Lameire, N .
KIDNEY INTERNATIONAL, 2003, 63 :S6-S10
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