Synthesis and Antifungal Activity of Novel Quinazolin-4(3H)-one Derivatives

被引：23

作者：

El-Hashash, Maher A. ^{[1
]}

Elshahawi, Manal M. ^{[1
]}

Ragab, Eman A. ^{[2
]}

Nagdy, Sanaa ^{[1
]}

机构：

[1] Ain Shams Univ, Dept Chem, Fac Sci, Cairo 11566, Egypt

[2] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2015年 / 45卷 / 19期

关键词：

Antifungal activity; benzoxazinone; quinazolinones; QUINAZOLINONE DERIVATIVES; BIOLOGICAL EVALUATION; ANALOGS; ANTIBACTERIAL; PYRAZOLE;

D O I：

10.1080/00397911.2015.1074697

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel group of 6-iodoquinazolin-4(3H)-one derivatives was prepared starting from 6-iodo-2-ethoxy-4H-3,1-benzoxazin-4-one (3) via action of various nitrogen nucleophiles such as primary and secondary amines, hydrazine hydrate, and its derivatives. The 3-amino-2-hydrazinyl-6-iodoquinazolin-4(3H)-one (15) was used as a key starting material to prepare new heterocyclic compounds. The structures of all synthesized compounds were inferred from the infrared, mass spectral, and H-1 NMR spectral data as well as elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated.

引用

页码：2240 / 2250

页数：11

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