The kinin-kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers

被引：53

作者：

Kashuba, Elena ^{[1
,2
]}

Bailey, James ^{[1
,2
,3
]}

Allsup, David ^{[1
,3
]}

Cawkwell, Lynn ^{[1
,2
]}

机构：

[1] Univ Hull, Postgrad Med Inst, Kingston Upon Hull HU6 7RX, N Humberside, England

[2] Hull York Med Sch, Kingston Upon Hull, N Humberside, England

[3] Hull & East Yorkshire NHS Trust, Queens Ctr Oncol & Haematol, Castle Hill Hosp, Kingston Upon Hull, N Humberside, England

来源：

BIOMARKERS | 2013年 / 18卷 / 04期

关键词：

Bradykinin; carcinogenesis; kinin-kallikrein system; kininogen; kinins; MOLECULAR-WEIGHT KININOGEN; PROSTATE-SPECIFIC ANTIGEN; I-CONVERTING-ENZYME; ENDOTHELIAL-CELL PROLIFERATION; HUMAN TISSUE KALLIKREIN; RECEPTOR SIGNALING PATHWAY; HUMAN-PLASMA PREKALLIKREIN; PROTEIN-COUPLED RECEPTORS; RENIN-ANGIOTENSIN SYSTEMS; BLOOD-PRESSURE REGULATION;

D O I：

10.3109/1354750X.2013.787544

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The kinin-kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of kininogens with the consequent release of bradykinin-related peptides. This system plays a crucial role in inflammation, vasodilation, smooth muscle contraction, cardioprotection, vascular permeability, blood pressure control, coagulation and pain. In this review, we will outline the physiology and pathophysiology of the KKS and also highlight the association of this system with carcinogenesis and cancer progression.

引用

页码：279 / 296

页数：18

共 170 条

[61]

GORDON EM, 1990, J LAB CLIN MED, V115, P463

[62]

Goyal J, 1998, CANCER RES, V58, P4782

[63] BRADYKININ DEGRADING ACTIVITY IN CULTURED HUMAN ENDOTHELIAL-CELLS [J].

GRAF, K ;

GRAFE, M ;

AUCHSCHWELK, W ;

BAUMGARTEN, CR ;

BOSSALLER, C ;

FLECK, E .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1992, 20 :S16-S20

[64] Mitogenic signalling by B2 bradykinin receptor in epithelial breast cells [J].

Greco, S ;

Muscella, A ;

Elia, MG ;

Romano, S ;

Storelli, C ;

Marsigliante, S .

JOURNAL OF CELLULAR PHYSIOLOGY, 2004, 201 (01) :84-96

[65] HIGH-MOLECULAR-WEIGHT KININOGEN BINDS TO UNSTIMULATED PLATELETS [J].

GUSTAFSON, EJ ;

SCHUTSKY, D ;

KNIGHT, LC ;

SCHMAIER, AH .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (01) :310-318

[66] The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades [J].

Gutkind, JS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (04) :1839-1842

[67] BRADYKININ RECEPTORS - PHARMACOLOGICAL PROPERTIES AND BIOLOGICAL ROLES [J].

HALL, JM .

PHARMACOLOGY & THERAPEUTICS, 1992, 56 (02) :131-190

[68] Bradykinin and its metabolite, Arg-Pro-Pro-Gly. Phe, are selective inhibitors of alpha-thrombin-induced platelet activation [J].

Hasan, AAK ;

Amenta, S ;

Schmaier, AH .

CIRCULATION, 1996, 94 (03) :517-528

[69] Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo [J].

Hassan, Sarmina ;

Sainz, Irma M. ;

Khan, Mohammad M. ;

Bradford, Harlan N. ;

Isordia-Salas, Irma ;

Kashem, Sakeen W. ;

Sartor, R. Balfour ;

Colman, Robert W. .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 292 (06) :H2959-H2965

[70] The Kallikrein-Kinin system [J].

Hillmeister, P. ;

Persson, P. B. .

ACTA PHYSIOLOGICA, 2012, 206 (04) :215-219

← 2 3 4 5 6 7 8 9 10 11 →