The kinin-kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers

被引：53
作者：
Kashuba, Elena [1 ,2 ]
Bailey, James [1 ,2 ,3 ]
Allsup, David [1 ,3 ]
Cawkwell, Lynn [1 ,2 ]
机构：
[1] Univ Hull, Postgrad Med Inst, Kingston Upon Hull HU6 7RX, N Humberside, England
[2] Hull York Med Sch, Kingston Upon Hull, N Humberside, England
[3] Hull & East Yorkshire NHS Trust, Queens Ctr Oncol & Haematol, Castle Hill Hosp, Kingston Upon Hull, N Humberside, England
来源：
BIOMARKERS | 2013年 / 18卷 / 04期
关键词：
Bradykinin; carcinogenesis; kinin-kallikrein system; kininogen; kinins; MOLECULAR-WEIGHT KININOGEN; PROSTATE-SPECIFIC ANTIGEN; I-CONVERTING-ENZYME; ENDOTHELIAL-CELL PROLIFERATION; HUMAN TISSUE KALLIKREIN; RECEPTOR SIGNALING PATHWAY; HUMAN-PLASMA PREKALLIKREIN; PROTEIN-COUPLED RECEPTORS; RENIN-ANGIOTENSIN SYSTEMS; BLOOD-PRESSURE REGULATION;
D O I：
10.3109/1354750X.2013.787544
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The kinin-kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of kininogens with the consequent release of bradykinin-related peptides. This system plays a crucial role in inflammation, vasodilation, smooth muscle contraction, cardioprotection, vascular permeability, blood pressure control, coagulation and pain. In this review, we will outline the physiology and pathophysiology of the KKS and also highlight the association of this system with carcinogenesis and cancer progression.
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收藏
页码：279 / 296
页数：18
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