Synthesis and Biological Evaluation of Novel Hydroxylphenethyl-S-DACOs as High Active Anti-HIV Agents

被引：2

作者：

Wu, Dao-Chun ^{[1
]}

Zhuang, Dao-Ming ^{[2
]}

Liu, Xiao-Feng ^{[1
]}

Lu, Li-He ^{[1
]}

Wang, Hua ^{[1
]}

Li, Cong ^{[1
]}

Lai, Christopher Cong ^{[3
]}

Li, Jing-Yun ^{[2
]}

He, Yan-Ping ^{[1
]}

机构：

[1] Yunnan Univ, Key Lab Med Chem Nat Resources, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China

[2] Acad Mil Med Sci, Inst Microbiol & Epidemiol, Beijing 100071, Peoples R China

[3] NCI, Biol Chem Lab, Ctr Canc Res, Frederick, MD 21702 USA

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2013年 / 10卷 / 03期

关键词：

Anti HIV-1 activity; Water-solubility; Molecular Docking; NNRTIs; Pyrimidone; S-DACOs; REVERSE-TRANSCRIPTASE INHIBITORS; DABO SERIES; PYRIMIDIN-4(3H)-ONES; DERIVATIVES; NNRTIS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel 5-alky-6-(cyclohexylmethyl)-2-((2-hydroxy-2-phenylethyl)thio)-pyrimidin-4(3H)-one derivatives were synthesized and their ability to inhibit HIV evaluated. The screening results revealed that compounds 2a-g had a favorable property in inhibiting HIV. The compounds 2b, in particular, showed a special potent anti-HIV activities with EC50 values of 0.003 mu M and CC50 values of 200 mu M. Preliminary structure-activity relationship (SAR) and molecular modeling analyses of these newly synthesized hydroxylphenethyl-S-DACOs are also discussed.

引用

页码：271 / 276

页数：6

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