HIV-2: the forgotten AIDS virus

被引：129
作者：
de Silva, Thushan I. [1 ]
Cotten, Matthew [1 ]
Rowland-Jones, Sarah L. [1 ,2 ]
机构：
[1] MRC Labs, Fajara, Gambia
[2] John Radcliffe Hosp, Weatherall Inst Mol Med, Med Res Council Human Immunol Unit, Oxford OX3 9DS, England
来源：
TRENDS IN MICROBIOLOGY | 2008年 / 16卷 / 12期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/j.tim.2008.09.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
HIV type 2 (HIV-2), a closely related retrovirus discovered a few years after HIV type 1, causes AIDS in only a minority of infected individuals. Determining why HIV-2 causes asymptomatic infection in most patients could further our understanding of HIV immunopathogenesis. Studies to date have suggested that both enhanced immune responses and lower viral replication could play a role. We summarize the important findings to date and highlight areas that warrant further exploration.
引用
收藏
页码：588 / 595
页数：8
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