Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol

被引：8

作者：

Barrientos, Ruth M. ^{[1
]}

Kitt, Meagan M. ^{[1
]}

D'Angelo, Heather M. ^{[1
]}

Watkins, Linda R. ^{[1
]}

Rudy, Jerry W. ^{[1
]}

Maier, Steven F. ^{[1
]}

机构：

[1] Univ Colorado, Ctr Neurosci, Dept Psychol & Neurosci, Boulder, CO 80309 USA

来源：

LEARNING & MEMORY | 2016年 / 23卷 / 12期

关键词：

PERIPHERAL INFECTION; CONSOLIDATION; IL-1-BETA;

D O I：

10.1101/lm.043489.116

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Here, we present data demonstrating that a 1 d Morris water maze training protocol is effective at producing stable, longterm spatial memory in both young (3 mo old) and aged (24 mo old) F344xBN rats. Four trials in each of four sessions separated by a 2.5 h ISI produced robust selective search for the platform 1 and 4 d after training, in both age groups. A 1 h ISI protocol did not produce good retention. Also, compressing the trials into just two sessions separated by a 2.5 h ISI produced limited retention in only young rats.

引用

页码：699 / 702

页数：4

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