Optical imaging of non-fluorescent nanodiamonds in live cells using transient absorption microscopy

被引：25

作者：

Chen, Tao ^{[1
]}

Lu, Feng ^{[2
]}

Streets, Aaron M. ^{[1
]}

Fei, Peng ^{[1
]}

Quan, Junmin ^{[2
]}

Huang, Yanyi ^{[1
]}

机构：

[1] Peking Univ, Coll Engn, Biodynam Opt Imaging Ctr BIOPIC, Beijing 100871, Peoples R China

[2] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Shenzhen, Peoples R China

来源：

NANOSCALE | 2013年 / 5卷 / 11期

基金：

美国国家科学基金会;

关键词：

RECEPTOR-MEDIATED ENDOCYTOSIS; CROSS-SECTIONS; FLUORESCENT NANODIAMONDS; CARBON NANOTUBES; CANCER; DELIVERY; OXIDE; THERAPY;

D O I：

10.1039/c3nr00308f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We directly observe non-fluorescent nanodiamonds in living cells using transient absorption microscopy. This label-free technology provides a novel modality to study the dynamic behavior of nanodiamonds inside the cells with intrinsic three-dimensional imaging capability. We apply this method to capture the cellular uptake of nanodiamonds under various conditions, confirming the endocytosis mechanism.

引用

页码：4701 / 4705

页数：5

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