Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression

被引：44
|
作者：
Yi Yongjun [1 ,2 ]
Huang Shuyun [1 ,2 ]
Chen Lei [1 ,2 ]
Chen Xiangrong [1 ,3 ]
Yang Zhilin [1 ,2 ]
Ke Yiquan [1 ,2 ]
机构：
[1] Southern Med Univ, Zhujiang Hosp, Dept Neurosurg, Guangzhou 510282, Guangdong, Peoples R China
[2] Southern Med Univ, Inst Neurosurg, Key Lab Brain Funct Repair & Regenerat Guangdong, Guangzhou 510282, Guangdong, Peoples R China
[3] Fujian Med Univ, Affiliated Hosp 2, Dept Neurosurg, Quanzhou 362000, Peoples R China
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 260卷 / 1-2期
基金：
美国国家科学基金会;
关键词：
Microglia; Glioma; Atorvastatin; MT1-MMP; Migration; Invasion; ENDOTHELIAL GROWTH-FACTOR; CELL LUNG CARCINOMAS; NF-KAPPA-B; MATRIX METALLOPROTEINASES; UP-REGULATION; INVASIVENESS; ACTIVATION; INHIBITION;
D O I：
10.1016/j.jneuroim.2013.04.020
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Microglia, the immune cells of the brain, often present in large numbers in gliomas, where they promote tumor growth and invasiveness. This study found that atorvastatin reduced the pro-tumorigenic effects of microglia on glioma migration and invasion by reducing the microglial expression of membrane type 1 metalloproteinase (MT1-MMP). The results suggest that down-regulation of MT1-MMP is controlled by a p38 MAPK pathway in microglia. Taken together, the results support further research on atorvastatin as a candidate for glioma therapy by targeting microglia. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：1 / 8
页数：8
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