Overcoming the stromal barrier: technologies to optimize drug delivery in pancreatic cancer

被引：57

作者：

Dimou, Anastasios ^{[3
]}

Syrigos, Konstantinos N. ^{[4
]}

Saif, Muhammad Wasif ^{[1
,2
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, New York, NY 10027 USA

[2] New York Presbyterian Hosp, Pancreas Ctr, New York, NY USA

[3] Albert Einstein Med Ctr, Dept Med, Philadelphia, PA 19141 USA

[4] Univ Athens, Sch Med, Oncol Unit, Dept Med 3, GR-11527 Athens, Greece

来源：

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2012年 / 4卷 / 05期

关键词：

chemotherapy; drug delivery; folfirinox; gemcitabine; pancreatic cancer; resistance; ALBUMIN-BOUND PACLITAXEL; TARGETED DELIVERY; IN-VITRO; CURCUMIN; ADENOCARCINOMA; GEMCITABINE; CELLS; INHIBITION; TUMORS; BLOOD;

D O I：

10.1177/1758834012446008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer has historically proven resistant to anticancer agents. On the one hand, drugs might be more efficient if higher levels could be achieved at the tumor site rather than the normal tissues. On the other hand, the thick stroma and the relative absence of abundant vessels may account at least partially for the failure of successive clinical trials to demonstrate effective treatments in this type of malignancy. In this context, the development and testing in clinical trials of treatment strategies that aim to optimize drug delivery is an important target in improving the prognosis of patients with pancreatic cancer.

引用

页码：271 / 279

页数：9

共 48 条

[1] A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone [J].

Altenburg, Jeffrey D. ;

Bieberich, Andrew A. ;

Terry, Colin ;

Harvey, Kevin A. ;

VanHorn, Justin F. ;

Xu, Zhidong ;

Davisson, V. Jo ;

Siddiqui, Rafat A. .

BMC CANCER, 2011, 11

[2] Bioconjugation of Calcium Phosphosilicate Composite Nanoparticles for Selective Targeting of Human Breast and Pancreatic Cancers In Vivo [J].

Barth, Brian M. ;

Sharma, Rahul ;

Altinoglu, Erhan I. ;

Morgan, Thomas T. ;

Shanmugavelandy, Sriram S. ;

Kaiser, James M. ;

McGovern, Christopher ;

Matters, Gail L. ;

Smith, Jill P. ;

Kester, Mark ;

Adair, James H. .

ACS NANO, 2010, 4 (03) :1279-1287

[3] CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans [J].

Beatty, Gregory L. ;

Chiorean, Elena G. ;

Fishman, Matthew P. ;

Saboury, Babak ;

Teitelbaum, Ursina R. ;

Sun, Weijing ;

Huhn, Richard D. ;

Song, Wenru ;

Li, Dongguang ;

Sharp, Leslie L. ;

Torigian, Drew A. ;

O'Dwyer, Peter J. ;

Vonderheide, Robert H. .

SCIENCE, 2011, 331 (6024) :1612-1616

[4] Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297 [J].

Berlin, JD ;

Catalano, P ;

Thomas, JP ;

Kugler, JW ;

Haller, DG ;

Benson, AB .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (15) :3270-3275

[5] Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis [J].

Bhattacharyya, Sanjib ;

Bhattacharya, Resham ;

Curley, Steven ;

McNiven, Mark A. ;

Mukherjee, Priyabrata .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (33) :14541-14546

[6] Polymeric nanoparticle-encapsulated curcumin (nanocurcumin"): A novel strategy for human cancer therapy" [J].

Bisht S. ;

Feldmann G. ;

Soni S. ;

Ravi R. ;

Karikar C. ;

Maitra A. ;

Maitra A. .

Journal of Nanobiotechnology, 5 (1)

[7] Hypoxia and cancer [J].

Brahimi-Horn, M. Christiane ;

Chiche, Johanna ;

Pouyssegur, Jacques .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2007, 85 (12) :1301-1307

[8] A Phase I Study of a 2-Day Lapatinib Chemosensitization Pulse Preceding Nanoparticle Albumin-Bound Paclitaxel for Advanced Solid Malignancies [J].

Chien, Amy J. ;

Illi, Julie A. ;

Ko, Andrew H. ;

Korn, Wolfgang M. ;

Fong, Lawrence ;

Chen, Lee-may ;

Kashani-Sabet, Mohammed ;

Ryan, Charles J. ;

Rosenberg, Jonathan E. ;

Dubey, Sarita ;

Small, Eric J. ;

Jahan, Thierry M. ;

Hylton, Nola M. ;

Yeh, Benjamin M. ;

Huang, Yong ;

Koch, Kevin M. ;

Moasser, Mark M. .

CLINICAL CANCER RESEARCH, 2009, 15 (17) :5569-5575

[9] FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer [J].

Conroy, Thierry ;

Desseigne, Francoise ;

Ychou, Marc ;

Bouche, Olivier ;

Guimbaud, Rosine ;

Becouarn, Yves ;

Adenis, Antoine ;

Raoul, Jean-Luc ;

Gourgou-Bourgade, Sophie ;

de la Fouchardiere, Christelle ;

Bennouna, Jaafar ;

Bachet, Jean-Baptiste ;

Khemissa-Akouz, Faiza ;

Pere-Verge, Denis ;

Delbaldo, Catherine ;

Assenat, Eric ;

Chauffert, Bruno ;

Michel, Pierre ;

Montoto-Grillot, Christine ;

Ducreux, Michel .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (19) :1817-1825

[10]

Dancer J, 2007, ONCOL REP, V18, P151

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